PMID- 1382329
OWN - NLM
STAT- MEDLINE
DCOM- 19921022
LR  - 20190911
IS  - 0166-2236 (Print)
IS  - 0166-2236 (Linking)
VI  - 15
IP  - 9
DP  - 1992 Sep
TI  - The nerve growth factor family of receptors.
PG  - 323-31
AB  - The neurotrophins, of which nerve growth factor (NGF) is the best known example, 
      support the survival and differentiation of chick embryo sensory neurons at 
      extremely low concentrations, 10(-12) M or less. These same neurons display two 
      different classes of neurotrophin receptors with dissociation constants of 
      10(-11) M and 10(-9) M, respectively, implying that only low occupancy of the 
      higher affinity receptor is required to mediate the biological actions of the 
      neurotrophins. Two structurally unrelated receptors have now been characterized 
      for NGF, and one of them, p75NGFR, serves as a receptor for all the known 
      neurotrophins. This is the receptor with a dissociation constant of 10(-9) M. The 
      second NGF receptor is a member of the trk family of tyrosine kinase receptors, 
      p140trkA. Other members, p145trkB and p145trkC, are receptors for brain-derived 
      neurtrophic factor (BDNF) and neurotrophin-4 (NT-4) and neurotrophin-3 (NT-3), 
      respectively, when assayed in fibroblasts. The specificity of neurotrophin 
      binding to these receptors appears to be much higher in neurons than in the 
      non-neuronal cells. The receptor p140trkA has many of the properties of the 
      higher affinity class of NGF receptors, and is able to mediate survival and 
      differentiation of the PC12 cell line, and cell growth and transformation in 
      fibroblast cells. On the other hand, expression of p75NGFR in several types of 
      cells displaying p140trkA induces a component of higher affinity NGF binding not 
      seen in its absence. Since it is unlikely that p75NGFR and p140trkA interact at 
      the level of the receptors, the crosstalk between receptors probably occurs 
      through their signal transduction mechanisms.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Meakin, S O
AU  - Meakin SO
AD  - Dept of Neurobiology, Stanford University School of Medicine, CA 94305-5401.
FAU - Shooter, E M
AU  - Shooter EM
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Trends Neurosci
JT  - Trends in neurosciences
JID - 7808616
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Receptors, Cell Surface/metabolism/*physiology
MH  - Receptors, Nerve Growth Factor
RF  - 84
EDAT- 1992/09/01 00:00
MHDA- 1992/09/01 00:01
CRDT- 1992/09/01 00:00
PHST- 1992/09/01 00:00 [pubmed]
PHST- 1992/09/01 00:01 [medline]
PHST- 1992/09/01 00:00 [entrez]
AID - 0166-2236(92)90047-C [pii]
AID - 10.1016/0166-2236(92)90047-c [doi]
PST - ppublish
SO  - Trends Neurosci. 1992 Sep;15(9):323-31. doi: 10.1016/0166-2236(92)90047-c.