PMID- 1384935
OWN - NLM
STAT- MEDLINE
DCOM- 19921215
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 590
IP  - 1-2
DP  - 1992 Sep 11
TI  - Effects of benzylpiperazine derivatives on the neurotoxicity of 
      3,4-methylenedioxymethamphetamine in rat brain.
PG  - 341-4
AB  - The neurotoxicity of 3,4-methylenedioxymethamphetamine (MDMA) in rat brain was 
      attenuated significantly by coadministration of several benzylpiperazines 
      (p-nitrobenzylpiperazine, p-chlorobenzylpiperazine and 1-piperonylpiperazine), 
      which were weak inhibitors for [3H]6-nitroquipazine binding to the 
      5-hydroxytryptamine (5-HT) transporter in rat brain. These results suggest that 
      these benzylpiperazines may inhibit the MDMA-induced neurotoxicity by a novel 
      neuropharmacological effect other than 5-HT uptake inhibition.
FAU - Hashimoto, K
AU  - Hashimoto K
AD  - Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan.
FAU - Maeda, H
AU  - Maeda H
FAU - Goromaru, T
AU  - Goromaru T
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Designer Drugs)
RN  - 0 (Piperazines)
RN  - 23145-88-2 (4-chlorobenzylpiperazine)
RN  - 32231-06-4 (1-piperonylpiperazine)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - 58198-49-5 (4-nitrobenzylpiperazine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/antagonists & 
      inhibitors/toxicity
MH  - Animals
MH  - Brain/*drug effects
MH  - Designer Drugs/*toxicity
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Piperazines/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Serotonin/metabolism
EDAT- 1992/09/11 00:00
MHDA- 1992/09/11 00:01
CRDT- 1992/09/11 00:00
PHST- 1992/09/11 00:00 [pubmed]
PHST- 1992/09/11 00:01 [medline]
PHST- 1992/09/11 00:00 [entrez]
AID - 0006-8993(92)91119-Y [pii]
AID - 10.1016/0006-8993(92)91119-y [doi]
PST - ppublish
SO  - Brain Res. 1992 Sep 11;590(1-2):341-4. doi: 10.1016/0006-8993(92)91119-y.