PMID- 1385785
OWN - NLM
STAT- MEDLINE
DCOM- 19920818
LR  - 20131121
IS  - 0232-7384 (Print)
IS  - 0232-7384 (Linking)
VI  - 99
IP  - 1
DP  - 1992
TI  - Effect of diabetes on the cholinergic enzyme activities of the urinary bladder 
      and the seminal vesicles of the rat.
PG  - 26-30
AB  - Choline acetyltransferase (ChAT) and acetyl-cholinesterase (AChE) activities were 
      determined in the seminal vesicles and in two regions of the urinary bladder, the 
      detrusor muscle and sphincter-trigon in control and streptozotocin(STZ)-induced 
      diabetic male Sprague-Dawley rats. In this study, STZ was administered (65 mg/kg, 
      i.p.) to induce diabetes 14 days prior to sacrifice and enzyme analysis. Diabetic 
      rats exhibited significant increase in both ChAT and AChE activities in the 
      detrusor compared to the control animals. Significant increases in ChAT activity, 
      however, were observed only in the seminal vesicles of diabetic animals compared 
      to the control group. AChE activity in the seminal vesicles and sphincter-trigon 
      region of the diabetic rats was not altered significantly. These findings suggest 
      that urogenital complications associated with diabetes may be related to the 
      dysfunction of the peripheral cholinergic system.
FAU - Wahba, Z Z
AU  - Wahba ZZ
AD  - College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, 
      Tallahassee 32307.
FAU - Soliman, K F
AU  - Soliman KF
FAU - Kolta, M G
AU  - Kolta MG
LA  - eng
GR  - RR03020/RR/NCRR NIH HHS/United States
GR  - RR0811/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - Exp Clin Endocrinol
JT  - Experimental and clinical endocrinology
JID - 8302802
RN  - 5W494URQ81 (Streptozocin)
RN  - EC 2.3.1.6 (Choline O-Acetyltransferase)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
SB  - IM
MH  - Acetylcholinesterase/analysis/*metabolism
MH  - Animals
MH  - Choline O-Acetyltransferase/analysis/*metabolism
MH  - Diabetes Mellitus, Experimental/*enzymology
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Seminal Vesicles/chemistry/*enzymology
MH  - Spectrophotometry
MH  - Streptozocin
MH  - Urinary Bladder/chemistry/*enzymology
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.1055/s-0029-1211127 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol. 1992;99(1):26-30. doi: 10.1055/s-0029-1211127.