PMID- 1387000
OWN - NLM
STAT- MEDLINE
DCOM- 19920921
LR  - 20190515
IS  - 0007-0920 (Print)
IS  - 1532-1827 (Electronic)
IS  - 0007-0920 (Linking)
VI  - 66
IP  - 2
DP  - 1992 Aug
TI  - The presence of scatter factor in patients with metastatic spread to the pleura.
PG  - 243-7
AB  - Pleural effusion fluid obtained from eleven patients with metastatic spread to 
      the pleura was screened for the ability to cause the dispersal--'scattering'--of 
      MDCK colonies in vitro. Four of these samples proved to be positive using this 
      assay. Of these two had titres high enough to warrant further purification on a 
      cation exchange Mono S column. Active material from both lung samples, eluted at 
      the same positions as factor from cultured human lung fibroblasts (MRC-5) and 
      human placenta but in a slightly different position to murine scatter factor. In 
      both cases the semi-purified active agent was identified as hepatocyte growth 
      factor/scatter factor (HGF/SF) using an ELISA detection system specific for human 
      HGF/SF. This is the first report identifying the presence of significant amounts 
      of HGF/SF in the pleura of patients where malignant spread has occurred.
FAU - Kenworthy, P
AU  - Kenworthy P
AD  - School of Biology, University of East Anglia, Norwich, UK.
FAU - Dowrick, P
AU  - Dowrick P
FAU - Baillie-Johnson, H
AU  - Baillie-Johnson H
FAU - McCann, B
AU  - McCann B
FAU - Tsubouchi, H
AU  - Tsubouchi H
FAU - Arakaki, N
AU  - Arakaki N
FAU - Daikuhara, Y
AU  - Daikuhara Y
FAU - Warn, R M
AU  - Warn RM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Cancer
JT  - British journal of cancer
JID - 0370635
RN  - 0 (Cytokines)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Animals
MH  - Breast Neoplasms/pathology/physiopathology
MH  - Cell Line
MH  - Cell Movement/drug effects
MH  - Cytokines/*isolation & purification/pharmacology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Hepatocyte Growth Factor
MH  - Humans
MH  - Lung Neoplasms/pathology/physiopathology
MH  - Neoplasm Metastasis/*physiopathology
MH  - Pleural Effusion, Malignant/*physiopathology
MH  - Uterine Cervical Neoplasms/pathology/physiopathology
PMC - PMC1977819
EDAT- 1992/08/01 00:00
MHDA- 1992/08/01 00:01
CRDT- 1992/08/01 00:00
PHST- 1992/08/01 00:00 [pubmed]
PHST- 1992/08/01 00:01 [medline]
PHST- 1992/08/01 00:00 [entrez]
AID - 10.1038/bjc.1992.251 [doi]
PST - ppublish
SO  - Br J Cancer. 1992 Aug;66(2):243-7. doi: 10.1038/bjc.1992.251.