PMID- 1387111
OWN - NLM
STAT- MEDLINE
DCOM- 19920918
LR  - 20051117
IS  - 0019-5189 (Print)
IS  - 0019-5189 (Linking)
VI  - 30
IP  - 1
DP  - 1992 Jan
TI  - Effects of prolactin and androgens on enzymes of carbohydrate metabolism in 
      prostate of castrated bonnet monkeys Macaca radiata (Geoffroy).
PG  - 8-11
AB  - Effects of prolactin (PRL), bromocriptine (Br), testosterone propionate (TP), 
      dihydrotestosterone (DHT) and the combinations of these androgens with PRL/Br on 
      the specific activities of caudal and cranial prostatic cellular enzymes involved 
      in carbohydrate metabolism in castrated mature bonnet monkeys have been studied. 
      Castration decreased all the enzymes studied such as hexokinase (HK), 
      6-phosphofructokinase (6-PFK), glyceraldehyde-3-phosphate dehydrogenase (G-3-PD), 
      pyruvate kinase (PK), glucose-6-phosphate dehydrogenase (G-6-PD) and 
      6-phosphogluconate dehydrogenase (6-PGD) in the cranial and caudal prostates. PRL 
      elevated the activities of all the enzymes above normal except G-3-PD of cranial 
      lobe. In the caudal lobe, PRL brought back the activities of HK, PFK, PK, G-6-PD 
      to normal and 6-PGD above normal except G-3-PD. TP/DHT treatment increased all 
      the enzymes in both the lobes. PRL given along with TP/DHT further enhanced the 
      androgen action with regard to HK, PK, G-6-PD and 6-PGD of cranial and PFK, 
      G-3-PD, PK, G-6-PD and 6-PGD of caudal lobe. Br treatment did not produce any 
      alteration of these enzymes in both the lobes. In the cranial lobe, during 
      Br+TP/DHT treatment, the stimulating effects of androgen were unaffected on all 
      the enzymes except PK. On the other hand in the caudal, the stimulatory effects 
      of androgens were affected and the activities of HK, PFK, PK and 6-PGD were 
      significantly decreased. The present results suggest that PRL has a direct as 
      well as a synergistic action with androgens on enzymes of EMP and HMP shunt in 
      the prostates of monkeys.
FAU - Arunakaran, J
AU  - Arunakaran J
AD  - Department of Endocrinology, University of Madras, Taramani, India.
FAU - Balasubramanian, K
AU  - Balasubramanian K
FAU - Srinivasan, N
AU  - Srinivasan N
FAU - Aruldhas, M M
AU  - Aruldhas MM
FAU - Govindarajulu, P
AU  - Govindarajulu P
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Exp Biol
JT  - Indian journal of experimental biology
JID - 0233411
RN  - 0 (Androgens)
RN  - 9002-62-4 (Prolactin)
RN  - EC 1.1.1.43 (Phosphogluconate Dehydrogenase)
RN  - EC 1.1.1.49 (Glucosephosphate Dehydrogenase)
RN  - EC 1.2.1.- (Glyceraldehyde-3-Phosphate Dehydrogenases)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 2.7.1.11 (Phosphofructokinase-1)
RN  - EC 2.7.1.40 (Pyruvate Kinase)
SB  - IM
MH  - Androgens/*pharmacology
MH  - Animals
MH  - *Carbohydrate Metabolism
MH  - Castration
MH  - Glucosephosphate Dehydrogenase/drug effects
MH  - Glyceraldehyde-3-Phosphate Dehydrogenases/drug effects
MH  - Hexokinase/drug effects
MH  - Macaca radiata
MH  - Male
MH  - Phosphofructokinase-1/drug effects
MH  - Phosphogluconate Dehydrogenase/drug effects
MH  - Prolactin/*pharmacology
MH  - Prostate/drug effects/*enzymology/metabolism
MH  - Pyruvate Kinase/drug effects
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
PST - ppublish
SO  - Indian J Exp Biol. 1992 Jan;30(1):8-11.