PMID- 1387731
OWN - NLM
STAT- MEDLINE
DCOM- 19921006
LR  - 20211203
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 257
IP  - 5074
DP  - 1992 Aug 28
TI  - The met proto-oncogene receptor and lumen formation.
PG  - 1258-61
AB  - The met proto-oncogene product (Met) and its ligand, hepatocyte growth 
      factor/scatter factor (HGF/SF), have been implicated in cell mitogenic response, 
      cell motility, and the promotion of the ordered spatial arrangement of tissue. By 
      means of confocal laser-scanning microscopy, it was shown that Met is expressed 
      in cells bordering lumen-like structures that resemble ducts in the human mammary 
      cell line T47D. In human breast tissue biopsies, Met staining was intense in 
      normal cells bordering mammary ducts but was reduced in adjacent tumor tissue. 
      Met staining in lumen-forming organs colocalizes with staining of antibody to 
      phosphotyrosine, which suggests that the Met receptor and its substrates may be 
      activated in lumen structures or ducts. HGF/SF treatment of human epithelial 
      carcinoma cell lines resulted in the formation of lumen-like structures in vitro. 
      Reduced expression of Met could be related to the extent of tumor cell 
      differentiation.
FAU - Tsarfaty, I
AU  - Tsarfaty I
AD  - ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research 
      and Development Center, Frederick, MD 21702.
FAU - Resau, J H
AU  - Resau JH
FAU - Rulong, S
AU  - Rulong S
FAU - Keydar, I
AU  - Keydar I
FAU - Faletto, D L
AU  - Faletto DL
FAU - Vande Woude, G F
AU  - Vande Woude GF
LA  - eng
GR  - N01-C0-74101/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Growth Substances)
RN  - 0 (MAS1 protein, human)
RN  - 0 (Proto-Oncogene Mas)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Adenocarcinoma/metabolism/pathology
MH  - Animals
MH  - Breast Neoplasms/metabolism/pathology
MH  - Cell Differentiation/genetics
MH  - Chromosomes, Human, Pair 7
MH  - Colonic Neoplasms/chemically induced/metabolism/pathology
MH  - Digestive System/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Growth Substances/pharmacology/*physiology
MH  - Hepatocyte Growth Factor
MH  - Humans
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Microscopy, Fluorescence
MH  - Microscopy, Immunoelectron
MH  - Proto-Oncogene Mas
MH  - Proto-Oncogene Proteins/*physiology
MH  - Proto-Oncogene Proteins c-met
EDAT- 1992/08/28 00:00
MHDA- 1992/08/28 00:01
CRDT- 1992/08/28 00:00
PHST- 1992/08/28 00:00 [pubmed]
PHST- 1992/08/28 00:01 [medline]
PHST- 1992/08/28 00:00 [entrez]
AID - 10.1126/science.1387731 [doi]
PST - ppublish
SO  - Science. 1992 Aug 28;257(5074):1258-61. doi: 10.1126/science.1387731.