PMID- 1390436
OWN - NLM
STAT- MEDLINE
DCOM- 19921116
LR  - 20220129
IS  - 0953-8178 (Print)
IS  - 0953-8178 (Linking)
VI  - 4
IP  - 9
DP  - 1992 Sep
TI  - MHC and malaria: the relationship between HLA class II alleles and immune 
      responses to Plasmodium falciparum.
PG  - 1055-63
AB  - In mice, immune responses to subunits of defined malaria antigens are regulated 
      by genes mapping within the MHC and it has been suggested that such genetic 
      restriction will be a major obstacle in the development of a human malaria 
      vaccine. The relationship between class II human leukocyte antigen (HLA) genes 
      and immune recognition of three candidate antigens for a vaccine against 
      Plasmodium falciparum malaria has been investigated in a human population living 
      in a malaria endemic area of West Africa. The study population was shown to be 
      extremely heterogeneous for HLA class II alleles and marked differences in 
      allelic frequency were detected between members of different ethnic groups. One 
      class II DQA-DQB combination (serological specificity DQw2) was particularly 
      common among members of the Fula ethnic group. This haplotype was significantly 
      associated with higher than average levels of antibody to a peptide epitope, 
      (EENV)6, of the malaria antigen Pf155/RESA. There was little evidence of 
      association between HLA class II genotype and cellular proliferative or 
      interferon gamma responses to the antigens tested. Overall, the number of 
      significant associations between immune responses and specific HLA class II 
      haplotypes was greater than would be expected by chance but less than would be 
      expected if class II-dependent genetic restriction were a major factor governing 
      human immune responses to malaria antigens. Thus, although some qualitative 
      variation in the immune response to vaccine antigens may occur in ethnically 
      different target populations, widespread HLA-associated nonresponsiveness to a 
      multivalent subunit malaria vaccine is unlikely.
FAU - Riley, E M
AU  - Riley EM
AD  - Medical Research Council Laboratories, Fajara, The Gambia.
FAU - Olerup, O
AU  - Olerup O
FAU - Bennett, S
AU  - Bennett S
FAU - Rowe, P
AU  - Rowe P
FAU - Allen, S J
AU  - Allen SJ
FAU - Blackman, M J
AU  - Blackman MJ
FAU - Troye-Blomberg, M
AU  - Troye-Blomberg M
FAU - Holder, A A
AU  - Holder AA
FAU - Greenwood, B M
AU  - Greenwood BM
LA  - eng
GR  - MC_U117532067/MRC_/Medical Research Council/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int Immunol
JT  - International immunology
JID - 8916182
RN  - 0 (Antibodies, Protozoan)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Alleles
MH  - Animals
MH  - Antibodies, Protozoan/*analysis
MH  - Child
MH  - Child, Preschool
MH  - *Genes, MHC Class II
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - Haplotypes
MH  - Humans
MH  - Middle Aged
MH  - Plasmodium falciparum/*immunology
EDAT- 1992/09/01 00:00
MHDA- 1992/09/01 00:01
CRDT- 1992/09/01 00:00
PHST- 1992/09/01 00:00 [pubmed]
PHST- 1992/09/01 00:01 [medline]
PHST- 1992/09/01 00:00 [entrez]
AID - 10.1093/intimm/4.9.1055 [doi]
PST - ppublish
SO  - Int Immunol. 1992 Sep;4(9):1055-63. doi: 10.1093/intimm/4.9.1055.