PMID- 1394103
OWN - NLM
STAT- MEDLINE
DCOM- 19921125
LR  - 20190815
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 62
IP  - 2
DP  - 1992 Sep
TI  - Longitudinal cytogenetic study of metaphase and interphase cells in childhood 
      monosomy 7 syndrome.
PG  - 160-5
AB  - A 15-year-old male with myelodysplastic syndrome (MDS) characterized by monosomy 
      7 was cytogenetically evaluated by metaphase karyotyping and fluorescence in situ 
      hybridization (FISH) of interphase cells at six different points during the 
      course of his disease. At diagnosis, there was complete agreement between 
      metaphase and interphase findings. Interphase analysis alone provided important 
      cytogenetic information on the first specimens received following intensive 
      combination chemotherapy and bone marrow transplantation where metaphase analyses 
      were uninformative. The detection of a minor post-treatment monosomy 7 population 
      by interphase but not metaphase studies may have identified minimal residual 
      disease prior to recurrence of MDS. From this longitudinal study, it is concluded 
      that metaphase and interphase cytogenetic analyses form complementary approaches 
      and that use of both provides greater analytical power when appropriate 
      chromosome markers are available.
FAU - Stanley, W S
AU  - Stanley WS
AD  - Department of Laboratory Medicine, Children's National Medical Center, 
      Washington, D.C. 20010.
FAU - Devine, G C
AU  - Devine GC
FAU - Murphy, B A
AU  - Murphy BA
FAU - Seibel, N
AU  - Seibel N
FAU - Dinndorf, P
AU  - Dinndorf P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adolescent
MH  - *Chromosomes, Human, Pair 7
MH  - Fluorescence
MH  - Humans
MH  - In Situ Hybridization
MH  - Interphase
MH  - Karyotyping
MH  - Longitudinal Studies
MH  - Male
MH  - Metaphase
MH  - *Monosomy
MH  - Myelodysplastic Syndromes/*genetics
EDAT- 1992/09/01 00:00
MHDA- 1992/09/01 00:01
CRDT- 1992/09/01 00:00
PHST- 1992/09/01 00:00 [pubmed]
PHST- 1992/09/01 00:01 [medline]
PHST- 1992/09/01 00:00 [entrez]
AID - 0165-4608(92)90256-8 [pii]
AID - 10.1016/0165-4608(92)90256-8 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1992 Sep;62(2):160-5. doi: 10.1016/0165-4608(92)90256-8.