PMID- 1395078
OWN - NLM
STAT- MEDLINE
DCOM- 19921104
LR  - 20190918
IS  - 0730-0077 (Print)
IS  - 0730-0077 (Linking)
VI  - 14
IP  - 5
DP  - 1992
TI  - Renal renin secretion rate and norepinephrine secretion rate in response to 
      centrally administered angiotensin-II: role of the medial basal forebrain.
PG  - 923-45
AB  - The influence that centrally administered angiotensin-II (ANG-II) and saralasin 
      (SAR) has on renal norepinephrine secretion rate (NESR) and renal renin secretion 
      rate (RSR) were studied. Rats were given thermal lesions of the medial basal 
      forebrain (MBF) or sham surgery. Twenty-four hours later the right kidney was 
      vascularly isolated (but neurally intact) and perfused with an artificial plasma 
      at either a constant pressure (100 mm Hg) or constant flow (600 microliters/min). 
      Renal perfusate was collected before (pre-injection) and at 10 min intervals 
      after central administration of peptides for determination of NESR and RSR. In 
      both perfusion models, intracerebroventricular (ICV) ANG-II increased renal NESR. 
      In MBF lesioned rats pre-injection renal NESR is reduced and the response to ICV 
      ANG-II is blocked. In both perfusion models ICV ANG-II decreases renal RSR. 
      Concomitant administration of SAR blocks the effect of ANG-II on both NESR and 
      RSR. MBF lesioned rats had significantly elevated pre-injection levels of RSR and 
      there is no change in RSR following ICV ANG-II. These experiments indicate that 
      centrally administered ANG-II increases renal NESR concomitant with a decrease in 
      renal RSR and that MBF lesions block those changes.
FAU - Weekley, L B
AU  - Weekley LB
AD  - Dept. of Veterinary Biosciences, College of Veterinary Medicine, Virginia 
      Polytechnic Institute and State University, Blacksburg 24061.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Exp Hypertens A
JT  - Clinical and experimental hypertension. Part A, Theory and practice
JID - 8207790
RN  - 11128-99-7 (Angiotensin II)
RN  - EC 3.4.23.15 (Renin)
RN  - H2AFV2HE66 (Saralasin)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Angiotensin II/*pharmacology
MH  - Animals
MH  - Female
MH  - Injections, Intraventricular
MH  - Kidney/*metabolism
MH  - Norepinephrine/*metabolism
MH  - Prosencephalon/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Renin/antagonists & inhibitors/*metabolism
MH  - Saralasin/pharmacology
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.3109/10641969209036227 [doi]
PST - ppublish
SO  - Clin Exp Hypertens A. 1992;14(5):923-45. doi: 10.3109/10641969209036227.