PMID- 1395305
OWN - NLM
STAT- MEDLINE
DCOM- 19921125
LR  - 20220317
IS  - 0009-921X (Print)
IS  - 0009-921X (Linking)
IP  - 284
DP  - 1992 Nov
TI  - Rapidly destructive arthropathy of the hip. Studies on bone resorptive factors in 
      joint fluid with a theory of pathogenesis.
PG  - 273-82
AB  - The mechanism of joint destruction in rapidly destructive coxopathy was studied 
      by analyzing bone resorptive factors in the joint fluid. Prostaglandins were 
      found to play a partial role in joint destruction. Some cases of rapidly 
      destructive coxopathy revealed elevated levels of interleukin-1 beta (IL-1 beta) 
      in the joint fluid. Electrophoretic analysis of proteolytic enzymes in 
      polyacrylamide gel containing sodium dodecyl sulfate and copolymerized gelatin 
      demonstrated that the resorptively active peptides have relative molecular 
      weights (M(r)) of approximately 92,000, 72,000, and lower than 60,000. Cultured 
      cells from synovia obtained perioperatively secreted matrix metalloproteinase 2 
      (MMP-2) with an M(r) of 72,000 and matrix metalloproteinase 3(MMP-3) with an M(r) 
      of 57,000. Synovial cells from the patients with coxarthrosis secreted fewer 
      proteolytic enzymes. Prostaglandins, IL-1 beta, MMP-2, and MMP-3 could act 
      synergetically as promotors in the rapid destruction of the hip joint.
FAU - Komiya, S
AU  - Komiya S
AD  - Department of Orthopaedic Surgery and Pathology, Faculty of Medicine, Kurume 
      University, Japan.
FAU - Inoue, A
AU  - Inoue A
FAU - Sasaguri, Y
AU  - Sasaguri Y
FAU - Minamitani, K
AU  - Minamitani K
FAU - Morimatsu, M
AU  - Morimatsu M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Orthop Relat Res
JT  - Clinical orthopaedics and related research
JID - 0075674
RN  - 0 (Interleukin-1)
RN  - 0 (Prostaglandins)
RN  - EC 3.4.- (Peptide Hydrolases)
RN  - EC 3.4.24.- (Metalloendopeptidases)
SB  - IM
MH  - Bone Matrix/chemistry
MH  - Bone Resorption/*metabolism
MH  - Electrophoresis, Polyacrylamide Gel
MH  - Humans
MH  - Interleukin-1/analysis
MH  - Metalloendopeptidases/analysis
MH  - Molecular Weight
MH  - Osteoarthritis, Hip/*metabolism
MH  - Peptide Hydrolases/analysis
MH  - Prostaglandins/analysis
MH  - Synovial Fluid/*chemistry
MH  - Synovial Membrane/cytology
EDAT- 1992/11/01 00:00
MHDA- 1992/11/01 00:01
CRDT- 1992/11/01 00:00
PHST- 1992/11/01 00:00 [pubmed]
PHST- 1992/11/01 00:01 [medline]
PHST- 1992/11/01 00:00 [entrez]
PST - ppublish
SO  - Clin Orthop Relat Res. 1992 Nov;(284):273-82.