PMID- 1395662
OWN - NLM
STAT- MEDLINE
DCOM- 19921106
LR  - 20190706
IS  - 0090-3493 (Print)
IS  - 0090-3493 (Linking)
VI  - 20
IP  - 10
DP  - 1992 Oct
TI  - Circulating interleukin-1 beta and tumor necrosis factor-alpha concentrations 
      after burn injury in humans.
PG  - 1414-9
AB  - OBJECTIVES: To measure plasma interleukin-1 beta (IL-1 beta) and tumor necrosis 
      factor-alpha (TNF alpha) concentrations after burn injury and to determine if 
      these concentrations relate to clinical status. DESIGN: Prospective assessment. 
      SETTING: Hospital burn unit. PATIENTS: Thirty-one patients with second- or 
      third-degree burns, covering 10% to 95% of body surface area. MEASUREMENTS AND 
      MAIN RESULTS: Initial concentrations of IL-1 beta were increased (mean 188 +/- 31 
      pg/mL), and the concentrations for each patient correlated with body temperature 
      at the time of the blood sample (rho = 0.51, p < .015) (rho is a nonparametric 
      statistical measure; a nonparametric analysis is mandatory for data that is 
      categorical [Acute Physiology and Chronic Health Evaluation, APACHE, scores] and 
      data that are not normally distributed [IL-1 beta and tumor necrosis factor, TNF, 
      data]). Mean TNF alpha concentrations were initially 264 +/- 132 pg/mL, and these 
      concentrations were positively related to body temperature (rho = 0.41, p < .05) 
      and inversely related to the total WBC count (rho = -0.45, p < .025). Through the 
      course of hospitalization, plasma cytokine levels fluctuated, but transient 
      increases (sometimes into the nanogram/mL range) did not consistently correspond 
      to changes in clinical signs or severity of illness, as determined by APACHE II 
      scores. The maximum plasma cytokine levels in any patient were not related to 
      age, but maximum IL-1 beta concentrations were inversely related to burn size 
      (rho = -0.46, p < .015). The final IL-1 beta concentrations measured in the 
      patients who died (n = 7) were significantly less than measurements in surviving 
      patients matched for burn size and age taken at approximately the same time after 
      admission. CONCLUSIONS: These results indicate that early after burn injury there 
      is a correspondence of IL-1 beta and TNF alpha with certain host responses, but 
      these correlations disappear with the progression of illness. In general, IL-1 
      beta and TNF alpha appear to be poor indicators of prognosis during burn injury; 
      however, the association of mortality with low circulating IL-1 beta values 
      supports the concept of IL-1 beta as being an essential mediator of host 
      defenses.
FAU - Cannon, J G
AU  - Cannon JG
AD  - Department of Medicine, New England Medical Center, Tufts University School of 
      Medicine, Boston, MA.
FAU - Friedberg, J S
AU  - Friedberg JS
FAU - Gelfand, J A
AU  - Gelfand JA
FAU - Tompkins, R G
AU  - Tompkins RG
FAU - Burke, J F
AU  - Burke JF
FAU - Dinarello, C A
AU  - Dinarello CA
LA  - eng
GR  - AI-15614/AI/NIAID NIH HHS/United States
GR  - GM-07035/GM/NIGMS NIH HHS/United States
GR  - GM21700/GM/NIGMS NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Crit Care Med
JT  - Critical care medicine
JID - 0355501
RN  - 0 (Interleukin-1)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Body Surface Area
MH  - Body Temperature
MH  - Burn Units
MH  - Burns/*blood/diagnosis/mortality
MH  - Hospitals, General
MH  - Humans
MH  - Interleukin-1/*blood
MH  - Leukocyte Count
MH  - Massachusetts/epidemiology
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Radioimmunoassay
MH  - Severity of Illness Index
MH  - Survival Rate
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/*analysis
EDAT- 1992/10/01 00:00
MHDA- 1992/10/01 00:01
CRDT- 1992/10/01 00:00
PHST- 1992/10/01 00:00 [pubmed]
PHST- 1992/10/01 00:01 [medline]
PHST- 1992/10/01 00:00 [entrez]
AID - 10.1097/00003246-199210000-00009 [doi]
PST - ppublish
SO  - Crit Care Med. 1992 Oct;20(10):1414-9. doi: 10.1097/00003246-199210000-00009.