PMID- 1397260
OWN - NLM
STAT- MEDLINE
DCOM- 19921104
LR  - 20190620
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 310
IP  - 2
DP  - 1992 Sep 28
TI  - Fc epsilon receptor mediated Ca2+ influx into mast cells is modulated by the 
      concentration of cytosolic free Ca2+ ions.
PG  - 123-8
AB  - The relationship between the Fc epsilon receptor mediated stimulation of mast 
      cells and the Ca2+ signal it induces were studied using thapsigargin (TG), a 
      blocker of the endoplasmic reticulum Ca2+ pump. TG induced, in mucosal mast cells 
      (RBL-2H3 line), a dose-dependent and an InsP3-independent increase in [Ca2+]i 
      (from resting levels of 83-150 nM to 600-680 nM), and a secretory response 
      amounting to 30-50% of that observed upon Fc epsilon RI clustering. The TG 
      induced rise of [Ca2+]i is most probably provided by both arrest of its uptake by 
      the endoplasmic reticulum and influx from the medium. Thus, Ca2+ influx in mast 
      cells may be modulated by the [Ca2+]i level.
FAU - Dar, O
AU  - Dar O
AD  - Department of Chemical Immunology, Weizmann Institute of Science, Rehovot Israel.
FAU - Pecht, I
AU  - Pecht I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Cations, Divalent)
RN  - 0 (Inositol Phosphates)
RN  - 0 (Receptors, IgE)
RN  - 0 (Terpenes)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 67526-95-8 (Thapsigargin)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Biological Transport
MH  - Calcium/*metabolism
MH  - Cations, Divalent
MH  - Cytosol/*metabolism
MH  - Immunoglobulin E/*metabolism
MH  - Inositol Phosphates/biosynthesis
MH  - Mast Cells/drug effects/*metabolism
MH  - Rats
MH  - Receptors, IgE/*metabolism
MH  - Signal Transduction
MH  - Terpenes/pharmacology
MH  - Thapsigargin
EDAT- 1992/09/28 00:00
MHDA- 1992/09/28 00:01
CRDT- 1992/09/28 00:00
PHST- 1992/09/28 00:00 [pubmed]
PHST- 1992/09/28 00:01 [medline]
PHST- 1992/09/28 00:00 [entrez]
AID - 0014-5793(92)81311-9 [pii]
AID - 10.1016/0014-5793(92)81311-9 [doi]
PST - ppublish
SO  - FEBS Lett. 1992 Sep 28;310(2):123-8. doi: 10.1016/0014-5793(92)81311-9.