PMID- 13980471
OWN - NLM
STAT- MEDLINE
DCOM- 19981101
LR  - 20181201
IS  - 0008-4409 (Print)
IS  - 0008-4409 (Linking)
VI  - 87
IP  - 19
DP  - 1962 Nov 10
TI  - Effect of a high-fat diet on the concentration of antihemophilic globulin and 
      factor V.
PG  - 1001-4
AB  - Experiments were carried out to determine whether a diet known to produce 
      coronary thrombosis in rats (Hartroft, O'Neal and Thomas(6)) could produce 
      increases in antihemophilic globulin (AHG), Factor V, and other coagulation 
      factors. In animals continuously fed the thrombogenic diet the concentration of 
      AHG increased to 186% of normal by two weeks and to 373% by eight weeks. The 
      concentration of Factor V rose to a lesser extent, reaching 138% compared to a 
      normal value of 100%. The prothrombin time, stypven time and plasma clotting time 
      also showed significant changes. After thrombin injections, the mortality from 
      massive thrombosis was significantly higher in fat-fed rats. As a considerable 
      number of rats on this diet were shown to develop spontaneous thrombosis, the 
      coagulation disturbances here described acquire added importance.
FAU - TEITELBAUM, J I
AU  - TEITELBAUM JI
FAU - COOPERBERG, A A
AU  - COOPERBERG AA
FAU - KALANT, N
AU  - KALANT N
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Med Assoc J
JT  - Canadian Medical Association journal
JID - 0414110
RN  - 0 (Blood Coagulation Factors)
RN  - 0 (Fats)
RN  - 0 (Globulins)
RN  - 113E3Z3CJJ (recombinant factor VIII SQ)
RN  - 9001-24-5 (Factor V)
RN  - 9001-27-8 (Factor VIII)
RN  - EC 3.4.21.5 (Thrombin)
SB  - OM
MH  - Animals
MH  - *Blood Coagulation
MH  - *Blood Coagulation Factors
MH  - *Blood Coagulation Tests
MH  - *Diet, High-Fat
MH  - *Factor V
MH  - *Factor VIII
MH  - *Fats
MH  - *Globulins
MH  - Rats
MH  - *Thrombin
MH  - *Thrombosis
PMC - PMC1849782
OTO - NLM
OT  - *FACTOR V
OT  - *FACTOR VIII
OT  - *FATS
OT  - *THROMBIN
OT  - *THROMBOSIS
EDAT- 1962/11/10 00:00
MHDA- 1962/11/10 00:01
PMCR- 1962/11/10
CRDT- 1962/11/10 00:00
PHST- 1962/11/10 00:00 [pubmed]
PHST- 1962/11/10 00:01 [medline]
PHST- 1962/11/10 00:00 [entrez]
PHST- 1962/11/10 00:00 [pmc-release]
PST - ppublish
SO  - Can Med Assoc J. 1962 Nov 10;87(19):1001-4.