PMID- 1399087
OWN - NLM
STAT- MEDLINE
DCOM- 19921113
LR  - 20190918
IS  - 0105-6263 (Print)
IS  - 0105-6263 (Linking)
VI  - 15
IP  - 3
DP  - 1992 Jun
TI  - Acidification of testicular and epididymal fluids in the rat after 
      surgically-induced varicocele.
PG  - 238-45
AB  - Experimental left varicocele (ELV) in adult rats produces a bilateral increase in 
      testicular blood-flow and temperature which may alter the intraluminal 
      environment in which sperm mature. The purpose of the present study was to 
      evaluate the effect of ELV on the in-situ pH, PCO2 and bicarbonate concentration 
      ([HCO3-]) in seminiferous tubules (ST), initial segment (IS), proximal caput 
      (PCP), middle caput (MCP), middle corpus (MCR), and proximal cauda epididymidis 
      (PCD) of the rat employing pH and PCO2 microelectrodes. Adult male rats with ELV 
      or sham-surgeries (control) were studied after 30 days. Relative to controls, ELV 
      significantly reduced the in-situ PCO2 in the testicular artery, ST, IS, PCP, 
      MCP, MCR and PCD. In spite of this reduction, all values remained significantly 
      higher than the systemic arterial blood PCO2. Values for in-situ pH in ST, IS, 
      PCP, MCP, MCR, and PCD of control rats were significantly more acidic than 
      systemic arterial blood. Furthermore, ELV decreased the pH in ST, IS, PCP, and 
      MCP when compared to control values. The calculated [HCO3-] in ST from control 
      animals was less than half that in systemic arterial blood and was reduced 
      further in IS, PCP, and MCP. Varicocele did not change the [HCO3-] in systemic 
      arterial blood but reduced markedly the values in ST, IS, PCP, and MCP. These 
      alterations in the in-situ pH, PCO2, and [HCO3-] in structures of the rat testis 
      and epididymis may play a role in the anti-spermatic effect of ELV.
FAU - Caflisch, C R
AU  - Caflisch CR
AD  - Department of Internal Medicine, University of Texas Medical Branch, Galveston 
      77550.
LA  - eng
GR  - HD 19988/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Int J Androl
JT  - International journal of andrology
JID - 8000141
RN  - 0 (Bicarbonates)
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Animals
MH  - Bicarbonates/metabolism
MH  - Carbon Dioxide/metabolism
MH  - Epididymis/*metabolism
MH  - Hydrogen-Ion Concentration
MH  - Male
MH  - Microelectrodes
MH  - Partial Pressure
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Seminiferous Tubules/metabolism
MH  - Varicocele/*metabolism
EDAT- 1992/06/01 00:00
MHDA- 1992/06/01 00:01
CRDT- 1992/06/01 00:00
PHST- 1992/06/01 00:00 [pubmed]
PHST- 1992/06/01 00:01 [medline]
PHST- 1992/06/01 00:00 [entrez]
AID - 10.1111/j.1365-2605.1992.tb01344.x [doi]
PST - ppublish
SO  - Int J Androl. 1992 Jun;15(3):238-45. doi: 10.1111/j.1365-2605.1992.tb01344.x.