PMID- 1400833
OWN - NLM
STAT- MEDLINE
DCOM- 19921118
LR  - 20190629
VI  - 580
IP  - 1-2
DP  - 1992 Sep 16
TI  - Determination of methamphetamine enantiomer ratios in urine by gas 
      chromatography-mass spectrometry.
PG  - 77-95
AB  - Analysis of the enantiomers of methamphetamine and its metabolite amphetamine is 
      an extremely important process for a number of scientific disciplines. From 
      studies of biological activity and mechanisms through determination of precursor 
      molecules in a criminal investigation are all served by this analytical 
      procedure. Utilization of gas chromatography-mass spectrometry with chiral 
      derivatizing reagents is the most common chiral procedure and produces excellent 
      results. Of the chiral derivatizing reagents available, the most widely used is 
      trifluoroacetyl-l-prolyl chloride (TPC). Utilization of other derivatives require 
      either synthesis by the analyst or have not shown themselves to provide as good a 
      separation as did the TPC reagent. Use of chiral stationary phases yield good 
      results but the disadvantages of temperature limits of these columns and the 
      narrow use to which the columns can be put has limited their utilization. A 
      significant utility of the chiral stationary phase is the ability to determine 
      the purity of a chiral derivatizing reagent. Even if not used for routine 
      analysis of enantiomers, utilization of this procedure can determine the purity 
      of a reagent such as TPC and allow for accurate calculation of actual amounts of 
      each enantiomer. This can be estimated using chiral derivatives on an achiral 
      column, but it is limited to the extent that it is not able to differentiate 
      enantiomeric impurity in the reagent versus the drug itself. Description of 
      chromatographic procedures primarily focusing on gas chromatographic-mass 
      spectrometric techniques but also including liquid chromatographic techniques 
      along with examples of extraction and derivatization procedures is the focus of 
      this review.
FAU - Cody, J T
AU  - Cody JT
AD  - Wilford Hall Medical Center, Lackland AFB, TX 78236-5300.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - J Chromatogr
JT  - Journal of chromatography
JID - 0427043
RN  - 44RAL3456C (Methamphetamine)
SB  - IM
MH  - *Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - Methamphetamine/*urine
MH  - Stereoisomerism
RF  - 56
EDAT- 1992/09/16 00:00
MHDA- 1992/09/16 00:01
CRDT- 1992/09/16 00:00
PHST- 1992/09/16 00:00 [pubmed]
PHST- 1992/09/16 00:01 [medline]
PHST- 1992/09/16 00:00 [entrez]
AID - 10.1016/0378-4347(92)80529-y [doi]
PST - ppublish
SO  - J Chromatogr. 1992 Sep 16;580(1-2):77-95. doi: 10.1016/0378-4347(92)80529-y.