PMID- 1400882
OWN - NLM
STAT- MEDLINE
DCOM- 19921113
LR  - 20071114
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 75
IP  - 4
DP  - 1992 Oct
TI  - Role of body fat distribution in the decline in insulin sensitivity and glucose 
      tolerance with age.
PG  - 1125-32
AB  - The relationships of body composition and physical fitness [maximal aerobic 
      capacity (VO2max)] to the decline in insulin sensitivity with age were examined 
      in healthy older (47-73 yr; n = 36) and young (19-36 yr; n = 13) men. In 18 older 
      men with normal glucose tolerance (OGTT), glucose disposal rates (M) during 
      hyperinsulinemic euglycemic clamps correlated negatively with the waist to hip 
      ratio (WHR; r = -0.77; P < .001) and percent body fat (r = -0.46; P < 0.05) and 
      positively with VO2max (r = 0.54; P < 0.05), but not with age. Similar 
      relationships existed in the 36 older men with a spectrum of OGTT responses; 
      however, only WHR was independently related to M (r2 = 0.32; P < 0.01). In the 
      older men with normal OGTT, M (mean +/- SEM, 7.88 +/- 0.43 mg/kg fat-free 
      mass.min) was not different from that in the young men (8.56 +/- 0.47; P = NS). 
      Furthermore, in older and young men with normal OGTT matched for WHR, percent 
      fat, or VO2max, glucose disposal was comparable at sequential 15-min intervals 
      during the clamp and in its relationship to insulin concentrations at the tissue 
      level (multicompartmental analysis). In contrast, despite higher steady state 
      plasma insulin levels during the clamp, M was significantly lower in the older 
      men with a higher WHR, greater percent fat, lower VO2max, or impaired OGTT. Thus, 
      in healthy older men up to the age of 73 yr, insulin sensitivity and glucose 
      tolerance are affected primarily by the regional body fat distribution, not age, 
      obesity, or VO2max.
FAU - Coon, P J
AU  - Coon PJ
AD  - Department of Medicine, Johns Hopkins University School of Medicine, Francis 
      Scott Key Medical Center, Baltimore, Maryland.
FAU - Rogus, E M
AU  - Rogus EM
FAU - Drinkwater, D
AU  - Drinkwater D
FAU - Muller, D C
AU  - Muller DC
FAU - Goldberg, A P
AU  - Goldberg AP
LA  - eng
GR  - KO8-AG00347/AG/NIA NIH HHS/United States
GR  - O1-RR-02719/RR/NCRR NIH HHS/United States
GR  - P01-AG-04402-05/AG/NIA NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adipose Tissue/*physiology
MH  - Adult
MH  - Aged
MH  - Aging/*physiology
MH  - Analysis of Variance
MH  - Blood Glucose/*metabolism
MH  - Body Composition/*physiology
MH  - Glucose Clamp Technique
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin Resistance/*physiology
MH  - Male
MH  - Middle Aged
MH  - Oxygen Consumption/physiology
MH  - Physical Fitness
MH  - Regression Analysis
EDAT- 1992/10/01 00:00
MHDA- 1992/10/01 00:01
CRDT- 1992/10/01 00:00
PHST- 1992/10/01 00:00 [pubmed]
PHST- 1992/10/01 00:01 [medline]
PHST- 1992/10/01 00:00 [entrez]
AID - 10.1210/jcem.75.4.1400882 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1992 Oct;75(4):1125-32. doi: 10.1210/jcem.75.4.1400882.