PMID- 1402390
OWN - NLM
STAT- MEDLINE
DCOM- 19921030
LR  - 20190516
IS  - 0741-5400 (Print)
IS  - 0741-5400 (Linking)
VI  - 52
IP  - 4
DP  - 1992 Oct
TI  - Exudation of proliferative macrophages in local inflammation in the peritoneum.
PG  - 421-4
AB  - Thioglycollate (TG)-elicited peritoneal macrophages (m phi s) were highly 
      proliferative and formed m phi colonies in vitro in the presence of m phi 
      colony-stimulating factor (M-CSF), while resident peritoneal m phi s did not. To 
      determine whether such proliferative m phi s are immigrant or locally activated 
      resident m phi s, mice depleted of bone marrow cells and circulating monocytes by 
      bone-seeking radiostrontium (89Sr) were injected intraperitoneally with TG. For 
      control (88Sr) and splenectomized (Spx) mice, more than 4 x 10(4) m phi 
      colony-forming cells (M-CFCs) per mouse were recovered in the peritoneal lavage 
      fluid 5 days after TG injection. 89Sr-treated mice, on the other hand, had only 
      20% of those in the control mice. Splenectomized and 89Sr-treated (Spx/89Sr) mice 
      showed further depletion of bone marrow cells and monocytes and, as expected, 
      total numbers of peritoneal M-CFCs were severely depressed to less than 1% of 
      those in the control mice. The results suggest that levels of peritoneal M-CFCs 
      are strongly dependent on the presence of radiosensitive bone marrow cells and 
      circulating monocytes, and resident peritoneal m phi s activated locally by 
      inflammatory stimuli do not form m phi colonies under the defined conditions.
FAU - Oghiso, Y
AU  - Oghiso Y
AD  - Division of Comparative Radiotoxicology, National Institute of Radiological 
      Sciences, Chiba, Japan.
FAU - Yamada, Y
AU  - Yamada Y
FAU - Shibata, Y
AU  - Shibata Y
LA  - eng
GR  - AI-17162/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 0 (Strontium Radioisotopes)
RN  - 0 (Thioglycolates)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Animals
MH  - Bone Marrow/physiology/radiation effects
MH  - Bone Marrow Cells
MH  - Cell Division/drug effects
MH  - Exudates and Transudates/*cytology
MH  - Female
MH  - Hematopoiesis/radiation effects
MH  - Hematopoietic Stem Cells/drug effects/radiation effects
MH  - Macrophage Colony-Stimulating Factor/pharmacology
MH  - Macrophages/*cytology/drug effects/radiation effects
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Models, Biological
MH  - Monocytes/physiology/radiation effects
MH  - Peritoneal Cavity/cytology
MH  - Peritonitis/blood/chemically induced/*pathology
MH  - Radiation Tolerance
MH  - Spleen/physiology/surgery
MH  - Splenectomy
MH  - Strontium Radioisotopes/pharmacology
MH  - Thioglycolates
EDAT- 1992/10/01 00:00
MHDA- 1992/10/01 00:01
CRDT- 1992/10/01 00:00
PHST- 1992/10/01 00:00 [pubmed]
PHST- 1992/10/01 00:01 [medline]
PHST- 1992/10/01 00:00 [entrez]
AID - 10.1002/jlb.52.4.421 [doi]
PST - ppublish
SO  - J Leukoc Biol. 1992 Oct;52(4):421-4. doi: 10.1002/jlb.52.4.421.