PMID- 1402883
OWN - NLM
STAT- MEDLINE
DCOM- 19921026
LR  - 20190630
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 59
IP  - 4
DP  - 1992 Oct
TI  - Beta-amyloid precursor protein isoforms in various rat brain regions and during 
      brain development.
PG  - 1316-24
AB  - To address the question of the possible functions of different Alzheimer's 
      disease beta-amyloid precursor protein (beta-APP) isoforms in the brain, we 
      studied their expression at different times during postnatal rat brain 
      development and in various regions of the adult rat brain. Polyclonal antibodies 
      directed to two peptide antigens were used. The majority of all beta-APP forms 
      was found to be soluble as revealed by western blot analysis. The highest level 
      of most beta-APP forms was reached in the second postnatal week, which is the 
      time of brain maturation and completion of synaptic connections. Strikingly high 
      concentrations of the Kunitz protease inhibitor-containing beta-APP were present 
      in the adult olfactory bulb, where continuous synaptogenesis occurs in the adult 
      animal. These findings support the idea of an involvement of beta-APPs in the 
      processes of cell differentiation and, probably, in the establishment of synaptic 
      contacts.
FAU - Loffler, J
AU  - Loffler J
AD  - Pharma Division, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
FAU - Huber, G
AU  - Huber G
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Amyloid beta-Protein Precursor/*metabolism
MH  - Animals
MH  - Animals, Newborn
MH  - Blotting, Western
MH  - Brain/growth & development/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Isomerism
MH  - Nerve Tissue Proteins/metabolism
MH  - Rats
MH  - Tissue Distribution
EDAT- 1992/10/01 00:00
MHDA- 1992/10/01 00:01
CRDT- 1992/10/01 00:00
PHST- 1992/10/01 00:00 [pubmed]
PHST- 1992/10/01 00:01 [medline]
PHST- 1992/10/01 00:00 [entrez]
AID - 10.1111/j.1471-4159.1992.tb08443.x [doi]
PST - ppublish
SO  - J Neurochem. 1992 Oct;59(4):1316-24. doi: 10.1111/j.1471-4159.1992.tb08443.x.