PMID- 1405002
OWN - NLM
STAT- MEDLINE
DCOM- 19921125
LR  - 20191028
IS  - 0047-1879 (Print)
IS  - 0047-1879 (Linking)
VI  - 34
IP  - 5
DP  - 1992 Sep
TI  - [Relationship between autoimmune diseases and pneumoconiosis].
PG  - 421-31
AB  - In recent years, with the aging of patients with pneumoconiosis, autoimmune 
      diseases as a complication have been observed. One of the reasons for this may be 
      that autoimmune diseases are prone to develop among the elderly. On the other 
      hand, it has been reported that dust itself, such as silica for example, has 
      adjuvant effect. A review of the recent literature published in Japan and abroad 
      was made to clarify the relationship between pneumoconiosis and autoimmune 
      diseases and the following results were obtained. 1) Disorders which accompany 
      pneumoconiosis: Scleroderma, rheumatoid arthritis, systemic lupus erythematosus 
      (SLE), and disorders of the kidney and liver have been reported. In Japan, about 
      30 cases of pneumoconiosis accompanied with autoimmune diseases have been 
      reported. In many of the reports, patients with pneumoconiosis and scleroderma 
      have a past history of exposure to silica. In both case studies and case control 
      studies, patients with rheumatoid arthritis and history of silica exposure are 
      prone to develop pneumoconiosis. 2) Immunological studies of patients with 
      pneumoconiosis: As for humoral immunity, elevation of polyclonal gamma-globulin, 
      especially IgG, has been often reported together with high positive rate of 
      autoantibodies such as antinuclear antibodies. In cellular immunity, decreased 
      delayed type skin reaction and decreased CD4/8 ratio have been reported. In human 
      leukocyte antigen (HLA) typing the elevated frequency of DR4 has been reported. 
      In the study of BAL increased production of superoxide anion O2- by alveolar 
      macrophages has been observed. 3) EXPERIMENTAL STUDIES: Silica is well known for 
      its toxicity to cells and also for its adjuvant effect. In the German Democratic 
      Republic, patients with scleroderma and history of long term silica exposure are 
      recognized as patients with occupational disease even though pneumoconiosis is 
      not clearly demonstrated on X-ray film. It is difficult from this review to nrake 
      a definite conclusion regarding the relation between silicosis and autoimmune 
      diseases. There is a need to repeat this review of the literature on autoimmune 
      diseases and pneumoconiosis in the near future.
FAU - Matsuoka, Y
AU  - Matsuoka Y
AD  - Central Health Supervision Office, East Japan Railway Company.
FAU - Tomita, M
AU  - Tomita M
FAU - Yoshino, I
AU  - Yoshino I
FAU - Hosoda, Y
AU  - Hosoda Y
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Sangyo Igaku
JT  - Sangyo igaku. Japanese journal of industrial health
JID - 0150531
SB  - IM
MH  - Aging/immunology
MH  - Antibody Formation
MH  - Arthritis, Rheumatoid/complications
MH  - Autoimmune Diseases/*complications/immunology
MH  - Humans
MH  - Kidney Diseases/complications
MH  - Lupus Erythematosus, Systemic/complications
MH  - Pneumoconiosis/*complications/immunology
RF  - 64
EDAT- 1992/09/01 00:00
MHDA- 1992/09/01 00:01
CRDT- 1992/09/01 00:00
PHST- 1992/09/01 00:00 [pubmed]
PHST- 1992/09/01 00:01 [medline]
PHST- 1992/09/01 00:00 [entrez]
AID - 10.1539/joh1959.34.421 [doi]
PST - ppublish
SO  - Sangyo Igaku. 1992 Sep;34(5):421-31. doi: 10.1539/joh1959.34.421.