PMID- 1409476
OWN - NLM
STAT- MEDLINE
DCOM- 19921112
LR  - 20161209
IS  - 0755-4982 (Print)
IS  - 0755-4982 (Linking)
VI  - 21
IP  - 26
DP  - 1992 Jul 22
TI  - [Functional coupling of the left ventriculo-arterial system and aging in man].
PG  - 1222-6
AB  - In a haemodynamic and angiographic study at rest conducted in 25 men aged from 22 
      to 68 years who had no more than another risk factor for arterial disease and 
      showed no evidence of cardiac or arterial disease several parameters were 
      measured or calculated. Firstly, a global index of arterial system function (Ea) 
      and its various factors: Ea = ESP/SV [ESP: left ventricular end-systolic 
      pressure; SV: systolic volume]; Ea = (HR x TSR)+Ea' [HR: heart rate/min; TSR: 
      total systemic resistance] where Ea' = (ESP - AoP/SV) [AoP: mean aortic 
      pressure]. Secondly, the parameters concerning the left ventricle were the mass 
      (m) and the m/EDV ratio [EDV: end-diastolic volume] and indices of the left 
      ventricular systolic and diastolic functions, such as ELV = ESP/ESV [ESV: 
      end-systolic volume], kp: the volumic distensibility module of the left 
      ventricular chamber; relations EF - o ES [EF: ejection fraction; o ES: 
      end-systolic constraint], and kp - m/EDV as indice of left ventricular muscle 
      distensibility. In parallel with the subjects' age, Ea increased by joint 
      augmentation of TSR and Ea' while m, m/EDV, ELV and kp also significantly 
      increased. The inotropic quality of the left ventricular muscle and its intrinsic 
      distensibility were found to be decreased in a few subjects aged over 45. Ea/ELV 
      (reverse of ejection fraction -1) tended to increase (ELV relatively less than 
      Ea), but this increase was not significant (P = 0.10). These results show that in 
      the ageing man the improvement observed in the ejection fraction of the left 
      ventricular pump corresponds roughly to the degradation of the arterial system 
      transfer function, and the arterial system-left ventricle coupling, evaluated by 
      the Ea/ELV ratio, is maintained (better in fact than in arterial hypertension and 
      heart failure). This improvement is achieved by increases of m and, chiefly, 
      m/EDV which compensate for both the increase of Ea and the relative decline of 
      left ventricular muscle contractile quality. There is a disorder of the left 
      ventricular pump diastolic function which is due to geometric changes in the 
      chamber and to changes in the intrinsic distensibility of the left ventricular 
      muscle.
FAU - Dahan, M
AU  - Dahan M
AD  - Service de Cardiologie, Hopital Bichat, Paris.
FAU - Merillon, J P
AU  - Merillon JP
FAU - Cohen-Solal, A
AU  - Cohen-Solal A
FAU - Paillole, C
AU  - Paillole C
FAU - Guiomard, A
AU  - Guiomard A
FAU - Gourgon, R
AU  - Gourgon R
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Couplage "fonctionnel" ventricule gauche-systeme arteriel et vieillissement chez 
      l'homme.
PL  - France
TA  - Presse Med
JT  - Presse medicale (Paris, France : 1983)
JID - 8302490
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction/physiology
MH  - Stroke Volume/physiology
MH  - Ventricular Function, Left/*physiology
EDAT- 1992/07/22 00:00
MHDA- 1992/07/22 00:01
CRDT- 1992/07/22 00:00
PHST- 1992/07/22 00:00 [pubmed]
PHST- 1992/07/22 00:01 [medline]
PHST- 1992/07/22 00:00 [entrez]
PST - ppublish
SO  - Presse Med. 1992 Jul 22;21(26):1222-6.