PMID- 1409655
OWN - NLM
STAT- MEDLINE
DCOM- 19921117
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 89
IP  - 20
DP  - 1992 Oct 15
TI  - Light regulates expression of brain-derived neurotrophic factor mRNA in rat 
      visual cortex.
PG  - 9444-8
AB  - Specific sensory input has profound transient and long-lasting effects on the 
      function of corresponding sensory cortical areas both during development and in 
      adulthood. To study whether neurotrophic factors might play a role in such 
      processes, we investigated the effects of light on the nerve growth factor and 
      brain-derived neurotrophic factor (BDNF) mRNA levels in rat visual cortex. 
      Keeping adult rats in the dark or preventing normal activity of retinal ganglion 
      cells by intraocular injection of tetrodotoxin significantly decreased the levels 
      of BDNF mRNA in the visual cortex but not in other cortical areas. Exposure to 
      light after a period in darkness rapidly restored the mRNA to control levels. 
      These alterations in visual input had no effect on nerve growth factor mRNA. The 
      mRNA of trkB, the putative signal-transducing receptor unit for BDNF, was also 
      decreased in darkness, although less than BDNF mRNA. BDNF mRNA levels increased 
      in the visual cortex of newborn rats after eye-opening. This increase is 
      retarded, although not completely abolished, by rearing the pups in darkness. 
      Thus, the levels of BDNF mRNA are rapidly regulated by sensory input during 
      development and in adulthood. BDNF may therefore play an important role in 
      formation and in activity-dependent modulation of specific connections in the 
      visual cortex.
FAU - Castren, E
AU  - Castren E
AD  - Department of Neurochemistry, Max Planck Institute for Psychiatry, 
      Planegg-Martinsried, Federal Republic of Germany.
FAU - Zafra, F
AU  - Zafra F
FAU - Thoenen, H
AU  - Thoenen H
FAU - Lindholm, D
AU  - Lindholm D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Oncogene Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (oncogene protein trk)
RN  - 4368-28-9 (Tetrodotoxin)
SB  - IM
GS  - trkB
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor
MH  - Gene Expression/drug effects/radiation effects
MH  - Light
MH  - Nerve Growth Factors/genetics
MH  - Nerve Tissue Proteins/*genetics
MH  - Oncogene Proteins/genetics
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Rats, Wistar
MH  - Tetrodotoxin/pharmacology
MH  - Visual Cortex/*physiology
PMC - PMC50148
EDAT- 1992/10/15 00:00
MHDA- 1992/10/15 00:01
PMCR- 1993/04/15
CRDT- 1992/10/15 00:00
PHST- 1992/10/15 00:00 [pubmed]
PHST- 1992/10/15 00:01 [medline]
PHST- 1992/10/15 00:00 [entrez]
PHST- 1993/04/15 00:00 [pmc-release]
AID - 10.1073/pnas.89.20.9444 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1992 Oct 15;89(20):9444-8. doi: 
      10.1073/pnas.89.20.9444.