PMID- 1412054
OWN - NLM
STAT- MEDLINE
DCOM- 19921106
LR  - 20161123
IS  - 0040-3709 (Print)
IS  - 0040-3709 (Linking)
VI  - 45
IP  - 6
DP  - 1992 Jun
TI  - Extraembryonic tissue changes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin and 
      2,3,4,7,8-pentachlorodibenzofuran with a note on direction of maternal blood flow 
      in the labyrinth of C57BL/6N mice.
PG  - 611-27
AB  - Histologic changes in extraembryonic and embryonic tissues induced by 3 or 6 
      micrograms 2,3,7,8-tetrachlorodibenzo-p-dioxin/kg (TCDD) or 80 micrograms 
      2,3,4,7,8-pentachlorodibenzofuran/kg/day (4-PeCDF) were studied 24 h after the 
      last of four daily doses administered orally to C57BL/6N mice on days 10-13 of 
      pregnancy. Both test compounds ruptured (1) the embryo-maternal vascular barrier 
      in the labyrinth, which resulted in hemorrhage of embryonic blood into the 
      maternal circulation, (2) the visceral yolk sac membrane with the embryonic blood 
      from the vitelline vessels escaping into the uterine, exocelomic and amniotic 
      cavities, and (3) the maternal vascular spaces of the placental periphery 
      resulting in hemorrhages into the interconceptal space. The role of the 
      hemorrhagic lesions in the induction of cleft palate and hydronephrosis by the 
      two compounds remains to be investigated. The presence of embryonic nucleated 
      erythroblasts that hemorrhaged into the maternal lacunar network allowed the 
      identification of maternal venous channels in the placenta. It revealed that (1) 
      the labyrinth could be tentatively divided into two caudocranially oriented 
      zones, an arterial and a venous zone; (2) the maternal blood in the labyrinthine 
      lacunae circulated from the arterial to the venous zone, somewhat parallel to the 
      uterine axis; and (3) the largest maternal vessels in the center of the placenta 
      hitherto named the "central maternal artery," was in fact, venous.
FAU - Khera, K S
AU  - Khera KS
AD  - Toxicology Research Division, Health Protection Branch, Health & Welfare Canada, 
      Ottawa, Ontario.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Teratology
JT  - Teratology
JID - 0153257
RN  - 0 (Benzofurans)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - U4C2RV3124 (2,3,4,7,8-pentachlorodibenzofuran)
SB  - IM
CIN - Teratology. 1993 Jan;47(1):1-9. PMID: 8475451
MH  - Animals
MH  - Benzofurans/*pharmacology
MH  - Embryo, Mammalian/*drug effects
MH  - Erythroblasts/drug effects
MH  - Erythrocytes/drug effects
MH  - Female
MH  - Fetomaternal Transfusion/chemically induced
MH  - Liver/drug effects/embryology
MH  - Maternal-Fetal Exchange/*drug effects/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Placenta/*drug effects
MH  - Polychlorinated Dibenzodioxins/*pharmacology
MH  - Pregnancy
EDAT- 1992/06/01 00:00
MHDA- 1992/06/01 00:01
CRDT- 1992/06/01 00:00
PHST- 1992/06/01 00:00 [pubmed]
PHST- 1992/06/01 00:01 [medline]
PHST- 1992/06/01 00:00 [entrez]
AID - 10.1002/tera.1420450606 [doi]
PST - ppublish
SO  - Teratology. 1992 Jun;45(6):611-27. doi: 10.1002/tera.1420450606.