PMID- 1415663
OWN - NLM
STAT- MEDLINE
DCOM- 19921029
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 263
IP  - 3 Pt 2
DP  - 1992 Sep
TI  - Habituation of lactate release responding to stressful stimuli in rat prefrontal 
      cortex in vivo.
PG  - R722-7
AB  - The extracellular level of lactate is mainly dependent on functional glucose 
      metabolism in most brain cells regulated in part by neuronal activity. We 
      investigated the effect of environmental stimuli on lactate release in rat medial 
      prefrontal cortex (MPFC) by in vivo brain microdialysis. Lactate release was 
      clearly demonstrated to increase immediately and transiently from its 
      steady-state levels after various stimuli (tail pinch for 1 min, 100-dB white 
      noise for 5 min, and immobilization for 5 min). These stimuli-induced increments 
      were depressed after a second trial 1 h later in a manner consistent with 
      dishabituation to a novel stimulus and "below-zero" habituation by several 
      repetition. Likewise the local perfusion of dopamine or norepinephrine 
      transiently increased and then diminished the second perfusion-induced increase 
      in MPFC lactate release consistent with desensitization. These results suggest 
      the possibility that stressful stimuli produce one-trial habituation of lactate 
      release in MPFC via a mechanism involving the regulation of the catecholaminergic 
      system.
FAU - Takita, M
AU  - Takita M
AD  - Division of Mental Disorder Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry, Tokyo, Japan.
FAU - Mikuni, M
AU  - Mikuni M
FAU - Takahashi, K
AU  - Takahashi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Lactates)
RN  - 33X04XA5AT (Lactic Acid)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Acoustic Stimulation
MH  - Animals
MH  - Brain/metabolism
MH  - Diagnosis, Computer-Assisted
MH  - Dialysis/methods
MH  - Dopamine/pharmacology
MH  - Extracellular Space/metabolism
MH  - *Habituation, Psychophysiologic
MH  - Lactates/*metabolism
MH  - Lactic Acid
MH  - Male
MH  - Norepinephrine/pharmacology
MH  - Pain
MH  - Prefrontal Cortex/metabolism/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Restraint, Physical
MH  - Stress, Physiological/etiology/*metabolism
EDAT- 1992/09/01 00:00
MHDA- 1992/09/01 00:01
CRDT- 1992/09/01 00:00
PHST- 1992/09/01 00:00 [pubmed]
PHST- 1992/09/01 00:01 [medline]
PHST- 1992/09/01 00:00 [entrez]
AID - 10.1152/ajpregu.1992.263.3.R722 [doi]
PST - ppublish
SO  - Am J Physiol. 1992 Sep;263(3 Pt 2):R722-7. doi: 10.1152/ajpregu.1992.263.3.R722.