PMID- 1422835
OWN - NLM
STAT- MEDLINE
DCOM- 19921215
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 590
IP  - 1-2
DP  - 1992 Sep 11
TI  - Amastatin potentiates drinking elicited by osmotic stimuli: evidence for 
      peptidergic mediation of intracellular dehydration-induced thirst.
PG  - 271-6
AB  - Aminopeptidase inhibitors have been demonstrated to enhance the behavioral 
      effects of both exogenously applied and endogenously released neuropeptides. In 
      this study peptidase inhibitors were used as probes for involvement of central 
      neuropeptides in osmotically-induced drinking behavior. Intracerebroventricular 
      (i.c.v.) injections of amastatin, an aminopeptidase A inhibitor, potentiated 
      water intake induced by subcutaneous injections of hypertonic saline. Drinking 
      responses to i.c.v. infusions of hypertonic saline were also enhanced when 
      amastatin was added to the infusions. The effect was not attenuated by the 
      angiotensin receptor antagonist, [Sar1, Thr8]angiotensin II, which suggests that 
      angiotensins do not play a role in the over-drinking. Drinking responses to 
      centrally infused hypertonic saline were not enhanced by i.c.v. thiorphan, an 
      endopeptidase inhibitor; this provides evidence that the effects of amastatin are 
      specific for a particular class of peptidases. These results suggest that there 
      is a role for an endogenous, non-angiotensinergic brain peptide in the mediation 
      of osmotic thirst.
FAU - Sullivan, M J
AU  - Sullivan MJ
AD  - Department of Psychology, University of Iowa, Iowa City 52242.
FAU - Johnson, A K
AU  - Johnson AK
LA  - eng
GR  - HL 14388/HL/NHLBI NIH HHS/United States
GR  - HL 44546/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Angiotensin Receptor Antagonists)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Neuropeptides)
RN  - 0 (Oligopeptides)
RN  - 0 (Peptides)
RN  - 0 (Protease Inhibitors)
RN  - 0 (Saline Solution, Hypertonic)
RN  - 11128-99-7 (Angiotensin II)
RN  - 56832-47-4 (angiotensin II, Sar(1)-Thr(8)-)
RN  - 67655-94-1 (amastatin)
RN  - B79L7B5X3Z (Thiorphan)
RN  - EC 3.4.- (Endopeptidases)
RN  - EC 3.4.11.- (Aminopeptidases)
RN  - EC 3.4.11.7 (Glutamyl Aminopeptidase)
RN  - EC 3.4.15.- (dipeptidyl carboxypeptidase)
SB  - IM
MH  - Aminopeptidases/*antagonists & inhibitors
MH  - Angiotensin II/analogs & derivatives/pharmacology
MH  - Angiotensin Receptor Antagonists
MH  - Animals
MH  - *Anti-Bacterial Agents
MH  - Dehydration/*physiopathology
MH  - Drinking/*drug effects
MH  - Endopeptidases/drug effects
MH  - Glutamyl Aminopeptidase
MH  - Injections, Intraventricular
MH  - Male
MH  - Neuropeptides/*pharmacology/physiology
MH  - Oligopeptides/pharmacology
MH  - Osmolar Concentration
MH  - *Peptides
MH  - Protease Inhibitors/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Saline Solution, Hypertonic
MH  - Thiorphan/pharmacology
MH  - Thirst/*drug effects
EDAT- 1992/09/11 00:00
MHDA- 1992/09/11 00:01
CRDT- 1992/09/11 00:00
PHST- 1992/09/11 00:00 [pubmed]
PHST- 1992/09/11 00:01 [medline]
PHST- 1992/09/11 00:00 [entrez]
AID - 0006-8993(92)91105-N [pii]
AID - 10.1016/0006-8993(92)91105-n [doi]
PST - ppublish
SO  - Brain Res. 1992 Sep 11;590(1-2):271-6. doi: 10.1016/0006-8993(92)91105-n.