PMID- 1425639 OWN - NLM STAT- MEDLINE DCOM- 19921214 LR - 20190827 IS - 0301-5548 (Print) IS - 0301-5548 (Linking) VI - 65 IP - 4 DP - 1992 TI - Effects of isolated and combined exposures to whole-body vibration and noise on auditory-event related brain potentials and psychophysical assessment. PG - 376-82 AB - Auditory event-related brain potentials (ERP) in response to two different tone stimuli (1.1 kHz or 1 kHz, 80 dB, 50 ms; given by headphones at a regular interstimulus interval of 5 s with a probability distribution of 70:30) were recorded from 12 healthy male subjects (Ss) during four different conditions with two repetitions: A-60 dBA white noise (wN), no whole-body vibration (WBV); B-60 dBA wN plus sinusoidal WBV in the az-direction with a frequency of 2.01 Hz and acceleration of 2 m.s-2 root mean square; C-80 dBA wN, no WBV; D-80 dBA wN plus WBV. Each condition consisted of two runs of about 11 min interrupted by a break of 4 min. During the break with continuing exposure, but without auditory stimuli, Ss judged the difficulty of the tone-detection task and intensity of noise by means of cross-modality matching (CMM). Vibration-synchronous activity in the electrocardiogram was eliminated by a subtraction-technique. Noise caused an attenuation of the N1 and P2 amplitudes and prolongation of P3 latencies. The WBV did not cause systematic ERP effects. Condition B was associated with higher N1 and smaller P3 amplitudes. The factor "condition" had a significant effect on the peak latencies of P3 to target stimuli and the task difficulty judged by CMM. Both effects exhibited significant linear increases in the sequence of conditions A, B, C, D. For the evaluation of exposure conditions at work, it can be suggested that noise has a strong systematic effect which can be enhanced by WBV.(ABSTRACT TRUNCATED AT 250 WORDS) FAU - Seidel, H AU - Seidel H AD - Federal Institute for Occupational Health, Berlin, Federal Republic of Germany. FAU - Bluthner, R AU - Bluthner R FAU - Martin, J AU - Martin J FAU - Menzel, G AU - Menzel G FAU - Panuska, R AU - Panuska R FAU - Ullsperger, P AU - Ullsperger P LA - eng PT - Journal Article PL - Germany TA - Eur J Appl Physiol Occup Physiol JT - European journal of applied physiology and occupational physiology JID - 0410266 SB - IM MH - Acoustic Stimulation MH - Adult MH - Electroencephalography MH - Electrooculography MH - Evoked Potentials, Auditory/*physiology MH - Humans MH - Male MH - Noise/*adverse effects MH - Psychoacoustics MH - Psychomotor Performance MH - Vibration/*adverse effects EDAT- 1992/01/01 00:00 MHDA- 1992/01/01 00:01 CRDT- 1992/01/01 00:00 PHST- 1992/01/01 00:00 [pubmed] PHST- 1992/01/01 00:01 [medline] PHST- 1992/01/01 00:00 [entrez] AID - 10.1007/BF00868144 [doi] PST - ppublish SO - Eur J Appl Physiol Occup Physiol. 1992;65(4):376-82. doi: 10.1007/BF00868144.