PMID- 1426090
OWN - NLM
STAT- MEDLINE
DCOM- 19921214
LR  - 20190907
IS  - 0531-5565 (Print)
IS  - 0531-5565 (Linking)
VI  - 27
IP  - 5-6
DP  - 1992 Sep-Dec
TI  - Effect of caloric restriction on age-associated cancers.
PG  - 575-81
AB  - Caloric restriction (CR) without malnutrition in mice and rats reduces the 
      incidence of spontaneous tumors and delays their appearance while increasing 
      maximum life span. These results depend largely on CR per se, and not on low 
      intakes of fat or other nutrients. Although most studies have tested CR imposed 
      early in life, CR started in midadulthood also retards cancer and aging. The 
      way(s) by which CR impedes cancers remain unclear, but possibilities include less 
      cellular oxidative damage, retarded immunologic aging, hormonal changes, less 
      energy available for cell proliferation, reduced exposure to dietary carcinogens 
      and promoters, enhanced DNA repair, and less carcinogen activation. Far less is 
      known about the relationship between caloric intake and cancer incidence in 
      humans; however, recent findings suggest a positive association for certain 
      cancers.
FAU - Weindruch, R
AU  - Weindruch R
AD  - Department of Medicine, University of Wisconsin-Madison 53706.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - *Energy Intake
MH  - Humans
MH  - Mice
MH  - Neoplasms/etiology/*prevention & control
MH  - Rats
RF  - 52
EDAT- 1992/09/01 00:00
MHDA- 1992/09/01 00:01
CRDT- 1992/09/01 00:00
PHST- 1992/09/01 00:00 [pubmed]
PHST- 1992/09/01 00:01 [medline]
PHST- 1992/09/01 00:00 [entrez]
AID - 10.1016/0531-5565(92)90012-o [doi]
PST - ppublish
SO  - Exp Gerontol. 1992 Sep-Dec;27(5-6):575-81. doi: 10.1016/0531-5565(92)90012-o.