PMID- 1427896
OWN - NLM
STAT- MEDLINE
DCOM- 19921217
LR  - 20190902
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 14
IP  - 3
DP  - 1992 Nov
TI  - Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and 
      an interleukin-8 receptor pseudogene to chromosome 2q35.
PG  - 685-91
AB  - Two human cDNA clones that encode different interleukin-8 (IL8) receptors have 
      recently been isolated. The interleukin-8 receptor type 1 (IL8R1) binds IL8 only, 
      whereas the interleukin-8 receptor type 2 (IL8R2) (previously designated IL8RA) 
      also binds growth regulated gene (GRO), and neutrophil activating protein-2 
      (NAP-2) with high affinity. In the process of screening a genomic library with 
      these cDNAs to obtain large clones for use in chromosomal localization studies, 
      we isolated an interleukin-8 receptor pseudogene (IL8RP) that bears greatest 
      similarity to IL8R2. Using Southern hybridization analysis of human x rodent 
      somatic cell hybrid DNAs with cDNA probes for IL8R1 and IL8R2 and probes from the 
      IL8RP locus, we assigned the three loci to chromosome 2; fluorescence in situ 
      hybridization (FISH) to metaphase chromosome preparations using genomic clones 
      from each locus refined this localization to chromosome 2, band q35, for all 
      three. By virtue of their chromosomal location, IL8R1 and IL8R2 may be considered 
      candidate genes for several human disorders in which the involved locus has been 
      mapped to distal 2q or that are associated with structural abnormalities of this 
      segment, including van der Woude syndrome and the neoplastic diseases 
      rhabdomyosarcoma and uterine leiomyomata. In addition, because this region of 
      chromosome 2q is homologous to proximal mouse chromosome 1 in the segment 
      containing the Lsh-Ity-Bcg locus involved in mediating host resistance to 
      infection with intracellular pathogens, examination for abnormalities of the 
      murine homologues of the IL8R genes should be considered in mice affected by 
      mutations of this locus.
FAU - Morris, S W
AU  - Morris SW
AD  - Department of Hematology-Oncology, St. Jude Children's Research Hospital, 
      Memphis, Tennessee 38105.
FAU - Nelson, N
AU  - Nelson N
FAU - Valentine, M B
AU  - Valentine MB
FAU - Shapiro, D N
AU  - Shapiro DN
FAU - Look, A T
AU  - Look AT
FAU - Kozlosky, C J
AU  - Kozlosky CJ
FAU - Beckmann, M P
AU  - Beckmann MP
FAU - Cerretti, D P
AU  - Cerretti DP
LA  - eng
SI  - GENBANK/M97502
SI  - GENBANK/S48543
SI  - GENBANK/S48548
SI  - GENBANK/S48549
SI  - GENBANK/S48551
SI  - GENBANK/S48556
SI  - GENBANK/S49009
SI  - GENBANK/S49010
SI  - GENBANK/S49011
SI  - GENBANK/X58468
GR  - P30-CA21765/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Interleukin-8A)
RN  - 9007-49-2 (DNA)
SB  - IM
GS  - IL8R1
GS  - IL8R2
GS  - IL8RP
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Southern
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 2
MH  - Cricetinae
MH  - DNA
MH  - Humans
MH  - Hybrid Cells
MH  - In Situ Hybridization, Fluorescence
MH  - Molecular Sequence Data
MH  - *Pseudogenes
MH  - Receptors, Immunologic/*genetics
MH  - Receptors, Interleukin-8A
EDAT- 1992/11/01 00:00
MHDA- 1992/11/01 00:01
CRDT- 1992/11/01 00:00
PHST- 1992/11/01 00:00 [pubmed]
PHST- 1992/11/01 00:01 [medline]
PHST- 1992/11/01 00:00 [entrez]
AID - S0888-7543(05)80169-7 [pii]
AID - 10.1016/s0888-7543(05)80169-7 [doi]
PST - ppublish
SO  - Genomics. 1992 Nov;14(3):685-91. doi: 10.1016/s0888-7543(05)80169-7.