PMID- 1428135
OWN - NLM
STAT- MEDLINE
DCOM- 19921218
LR  - 20041117
IS  - 0019-6061 (Print)
IS  - 0019-6061 (Linking)
VI  - 29
IP  - 7
DP  - 1992 Jul
TI  - Bronchial challenge with purified protein derivative of Mycobacterium 
      tuberculosis in asthma.
PG  - 867-70
AB  - Response to bronchial challenge (BC) with purified protein derivative of 
      Mycobacterium tuberculosis (PPD), was studied in children with bronchial asthma 
      and correlated with Mantoux test and serum immunoglobulin E (IgE) against PPD 
      (PPD-Sp IgE). Nearly 59% patients with bronchial asthma and 12.2% patients with 
      pulmonary tuberculosis gave positive BC. Children with extra-pulmonary 
      tuberculosis and normal children did not show positive BC. In asthma, 25% gave 
      early (EAR), 50% gave late (LAR) and 25% gave both early and late (DAR) asthmatic 
      response. Forced expiratory flow volumes in 1 sec (FEV.1) of 13 age and sex 
      matched asthmatic and normal children showed similar volumes before BC, however, 
      the values were significantly lower in asthma at 20 min (p less than 0.005) and 
      24 h (p less than 0.005) after BC. There was no relationship between response to 
      BC and the severity or chronicity of asthma. PPD-Sp IgE was estimated by the 
      radioimmunoassay method (Pharmacia Diagnostics). It was detected in 75% with 
      positive BC and none of the controls. The titre was of Phadebas RAST Class III in 
      66.7%, Class II in 22.2% and Class I in 11.1%. The presence of early Mantoux 
      reactions, positive BC with PPD and serum PPD-Sp IgE suggest the existence of 
      Type I or Arthus type of reactions to PPD, which could cause hyperreactive 
      airways in some cases of asthma.
FAU - Pherwani, A V
AU  - Pherwani AV
AD  - Department of Pediatrics, Institute of Child Health, Sir J.J. Group of Hospitals 
      and Grant Medical College, Bombay.
FAU - Patwari, V A
AU  - Patwari VA
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian Pediatr
JT  - Indian pediatrics
JID - 2985062R
RN  - 0 (Tuberculin)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Asthma/*immunology
MH  - *Bronchial Provocation Tests
MH  - Child
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Mycobacterium tuberculosis/*immunology
MH  - Tuberculin/*immunology
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
PST - ppublish
SO  - Indian Pediatr. 1992 Jul;29(7):867-70.