PMID- 142841
OWN - NLM
STAT- MEDLINE
DCOM- 19771014
LR  - 20191021
IS  - 0022-264X (Print)
IS  - 0022-264X (Linking)
VI  - 21
IP  - 2
DP  - 1977 Jun
TI  - The structure of the human cell interphase chromatin in the mosaic form of Down's 
      disease.
PG  - 85-93
AB  - In an earlier publication we reported that, by using fluorescent microscopy with 
      acridine orange (AO), we detected certain changes in the structure and function 
      of interphase nuclear chromatin of peripheral blood lymphocytes of subjects with 
      Down's disease (Fedorova, Inshakova and Spitkovsky, 1975). By employing the same 
      method with additional thermal action on the cells studied it was shown that some 
      of these changes were conditioned by the effect of the blood serum from a person 
      with Down's syndrome (Fedorova and Spitkovsky, 1976). The purpose of the present 
      work was to investigate the structure of the interphase chromatin of both disomic 
      and trisomic human cells residing in the same serum, that is, in mosaic subjects. 
      Small lymphocytes in the peripheral blood of mosaic mongols were selected for 
      study, complete trisomic mongols and healthy subjects being used as controls.
FAU - Fedorova, K N
AU  - Fedorova KN
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Ment Defic Res
JT  - Journal of mental deficiency research
JID - 0375401
RN  - 0 (Chromatin)
RN  - 0 (Lectins)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cells, Cultured
MH  - Child
MH  - Child, Preschool
MH  - Chromatin/*ultrastructure
MH  - DNA/metabolism
MH  - Down Syndrome/*blood
MH  - Female
MH  - Humans
MH  - Infant
MH  - Lectins/pharmacology
MH  - Lymphocytes/*ultrastructure
MH  - Male
MH  - Microscopy, Fluorescence
MH  - *Mosaicism
MH  - Nucleic Acid Denaturation
MH  - Temperature
MH  - Time Factors
EDAT- 1977/06/01 00:00
MHDA- 1977/06/01 00:01
CRDT- 1977/06/01 00:00
PHST- 1977/06/01 00:00 [pubmed]
PHST- 1977/06/01 00:01 [medline]
PHST- 1977/06/01 00:00 [entrez]
AID - 10.1111/j.1365-2788.1977.tb00028.x [doi]
PST - ppublish
SO  - J Ment Defic Res. 1977 Jun;21(2):85-93. doi: 10.1111/j.1365-2788.1977.tb00028.x.