PMID- 142924
OWN - NLM
STAT- MEDLINE
DCOM- 19771031
LR  - 20180214
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 23
IP  - 2
DP  - 1977
TI  - Quantitative histochemical studies of the hypothalamus. Control point enzymes 
      during the estrous cycle.
PG  - 76-87
AB  - Three control point enzymes of the Embden-Meyerhof pathway, hexokinase (HK), 
      phosphofructokinase (PFK) and pyruvate kinase (PK), have been measured in 
      individual hypothalamic nuclei during the 5-day estrous cycle of adult rats by 
      quantitative histochemical methods. PK levels, low during proestrus, rise to 
      maximum activity during estrus; this rise is significantly greater than on all 
      other days of the cycle in the lateral preoptic area (LP), ventromedial pars 
      medialis (VMM) and pars lateralis (VML) and posterior hypothalamic (Post) nuclei. 
      HK activity also rises from low proestrous levels during the cycle but, in 
      contrast to PK, reaches maximum activity during diestrus-1 (D-1) or diestrus-2 
      (D-2). PFK showed variable changes during the estrous cycle with peaks occurring 
      during estrus in some nuclei and during diestrus in others, but these changes 
      were not significantly different. These metabolic changes occur in specific 
      hypothalamic nuclei which have been shown by electrical stimulation, lesion 
      production, stereotaxic hormone implantation and localization of luteinizing 
      hormone-releasing factor experiments to have an important role in reproductive 
      physiology and sexual behavior.
FAU - Packman, P M
AU  - Packman PM
FAU - Bragdon, M J
AU  - Bragdon MJ
FAU - Boshans, R L
AU  - Boshans RL
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 2.7.1.11 (Phosphofructokinase-1)
RN  - EC 2.7.1.40 (Pyruvate Kinase)
SB  - IM
MH  - Animals
MH  - Cerebellar Cortex/enzymology
MH  - Cerebral Cortex/enzymology
MH  - Diestrus
MH  - *Estrus
MH  - Female
MH  - Hexokinase/*analysis
MH  - Histocytochemistry
MH  - Hypothalamus/analysis/*enzymology
MH  - Hypothalamus, Posterior/enzymology
MH  - Mammillary Bodies/enzymology
MH  - Phosphofructokinase-1/*analysis
MH  - Pregnancy
MH  - Preoptic Area/enzymology
MH  - Pyruvate Kinase/*analysis
MH  - Rats
MH  - Supraoptic Nucleus/enzymology
EDAT- 1977/01/01 00:00
MHDA- 1977/01/01 00:01
CRDT- 1977/01/01 00:00
PHST- 1977/01/01 00:00 [pubmed]
PHST- 1977/01/01 00:01 [medline]
PHST- 1977/01/01 00:00 [entrez]
AID - 10.1159/000122656 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1977;23(2):76-87. doi: 10.1159/000122656.