PMID- 142964
OWN - NLM
STAT- MEDLINE
DCOM- 19771020
LR  - 20190726
IS  - 0031-6768 (Print)
IS  - 0031-6768 (Linking)
VI  - 370
IP  - 1
DP  - 1977 Jul 29
TI  - Effects of increased cardiac mechanical performances on flow rates of cardiac 
      lymph in dogs.
PG  - 31-6
AB  - Relationship between flow rates of cardiac lymph (LF), and coronary blood flow 
      (CF), coronary perfusion pressure (PP), left ventricular peak systolic pressure 
      (LVSP) and heart rate (HR) was studied in open-chest dogs. Intra-coronary 
      administration of catecholamines (CA) and electrical stimulation of the cardiac 
      sympathetic nerve (ES) increased LF transiently with a concomitant rise in the 
      cardiac mechanical performance, while dipyridamole induced no change in LF in 
      spite of a marked increase in CF. Isoproterenol at does of 0.3 and 3x10(8) g/kg 
      induced an increasein LF to 119 +/- 4 and 167 +/- 20% (mean +/- SE); 
      norepinephrine, 0.3 and 3 X 10(7) g/kg, to 118 +/- r and 141 +/- 13%; ES AT 5 and 
      20 Hz, to 135 +/- 11 and 167 +/- 10%, respectively. Peak responses of LF 
      correlated with changes in LVSP (R = 0.59, N l1,P less than 0.001), CF Tr = 0.53, 
      n = 51, P less than 0.001), PP (r = 0.49, n = 51, P less than 0.001) but not with 
      changes in HR (r = 0.27, n = 51, 0.05 less than P less than 0.10). Cardiac pacing 
      also showed a poor correlation between the changes in LF and HR under the same 
      LVSP within the changes in HR up to 134% of control value (r = -0.12, n = 17, P 
      GREATER THAN 0.50). It is concluded that LF is independent of changes in HR, and 
      increased LF after CA or ES may be caused mainly by an augmented propulsive 
      force.
FAU - Takenaka, F
AU  - Takenaka F
FAU - Araki, H
AU  - Araki H
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Pflugers Arch
JT  - Pflugers Archiv : European journal of physiology
JID - 0154720
RN  - 64ALC7F90C (Dipyridamole)
RN  - L628TT009W (Isoproterenol)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - *Blood Flow Velocity
MH  - *Blood Pressure
MH  - Coronary Vessels
MH  - Dipyridamole
MH  - Dogs
MH  - *Heart Rate
MH  - Heart Ventricles
MH  - Isoproterenol/pharmacology
MH  - Lymph/*physiology
MH  - Norepinephrine/pharmacology
MH  - Rheology
EDAT- 1977/07/29 00:00
MHDA- 1977/07/29 00:01
CRDT- 1977/07/29 00:00
PHST- 1977/07/29 00:00 [pubmed]
PHST- 1977/07/29 00:01 [medline]
PHST- 1977/07/29 00:00 [entrez]
AID - 10.1007/BF00707942 [doi]
PST - ppublish
SO  - Pflugers Arch. 1977 Jul 29;370(1):31-6. doi: 10.1007/BF00707942.