PMID- 1430355
OWN - NLM
STAT- MEDLINE
DCOM- 19921207
LR  - 20190709
IS  - 0190-9622 (Print)
IS  - 0190-9622 (Linking)
VI  - 27
IP  - 2 Pt 1
DP  - 1992 Aug
TI  - A characteristic cutaneous direct immunofluorescent pattern associated with 
      Ro(SS-A) antibodies in subacute cutaneous lupus erythematosus.
PG  - 194-8
AB  - BACKGROUND: Antibodies to Ro(SS-A) are present in most patients with subacute 
      cutaneous lupus erythematosus (SCLE). Patients with SCLE also have cutaneous 
      immune deposits. However, no correlation of Ro(SS-A) antibodies with immune 
      deposits in skin biopsy specimens has been described. OBJECTIVE: The purpose of 
      this study is to describe characteristic direct immunofluorescence (IF) findings 
      in 32 patients and their association with serum antibodies and clinical 
      diagnosis. METHODS: Serum from patients with characteristic cutaneous direct IF 
      findings was examined for antinuclear antibodies by indirect IF and for 
      antibodies to ribonucleoprotein, Sm, Ro(SS-A), and La(SS-B) by gel 
      immunodiffusion. RESULTS: Twenty-two of 32 patients who exhibited discrete 
      speckled IgG staining predominantly, but not exclusively, of the basal cell 
      cytoplasm had SCLE. Ro(SS-A) antibodies were identified in 23 of 26 patients and 
      Ro(SS-A) and/or La(SS-B) in 25 of 26 patients. CONCLUSION: Direct IF staining 
      characterized by discrete speckled IgG deposits in the basal cell cytoplasm is 
      associated with Ro(SS-A) antibodies and SCLE.
FAU - Valeski, J E
AU  - Valeski JE
AD  - IMMCO Diagnostics Inc., Buffalo, NY 14223.
FAU - Kumar, V
AU  - Kumar V
FAU - Forman, A B
AU  - Forman AB
FAU - Beutner, E H
AU  - Beutner EH
FAU - Chorzelski, T P
AU  - Chorzelski TP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Immunoglobulin G)
RN  - 0 (SS-A antibodies)
SB  - IM
MH  - Acute Disease
MH  - Antibodies, Antinuclear/*analysis/blood
MH  - *Fluorescent Antibody Technique
MH  - Humans
MH  - Immunoglobulin G/analysis
MH  - Lupus Erythematosus, Cutaneous/blood/*immunology/pathology
MH  - Skin/*immunology/pathology
EDAT- 1992/08/01 00:00
MHDA- 1992/08/01 00:01
CRDT- 1992/08/01 00:00
PHST- 1992/08/01 00:00 [pubmed]
PHST- 1992/08/01 00:01 [medline]
PHST- 1992/08/01 00:00 [entrez]
AID - 0190-9622(92)70169-G [pii]
AID - 10.1016/0190-9622(92)70169-g [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 1992 Aug;27(2 Pt 1):194-8. doi: 10.1016/0190-9622(92)70169-g.