PMID- 1431230
OWN - NLM
STAT- MEDLINE
DCOM- 19921207
LR  - 20190723
IS  - 0022-202X (Print)
IS  - 0022-202X (Linking)
VI  - 99
IP  - 5
DP  - 1992 Nov
TI  - Keloid fibroblasts exhibit an altered response to TGF-beta.
PG  - 650-5
AB  - Treatment with transforming growth factor beta 1 (TGF-beta 1) results in 
      stimulation of total protein synthesis in normal dermal fibroblasts but not in 
      keloid fibroblasts, suggesting that the TGF-beta regulatory program is altered in 
      keloid fibroblasts. However, both keloid and normal fibroblasts treated with 
      TGF-beta 1 exhibit accelerated fibronectin biosynthesis, indicating that keloid 
      cells can respond to TGF-beta 1. In the absence of serum, the TGF-beta 1-induced 
      increase in fibronectin biosynthesis occurs more rapidly in keloid fibroblasts, 
      also suggesting modification of this regulatory pathway. The TGF-beta 1-mediated 
      increase in keloid fibronectin production is independent of the steroid 
      regulatory pathway for fibronectin, which accelerates synthesis by means of a 
      post-transcriptional mechanism. Thus, TGF-beta 1 stimulation of fibronectin 
      production in keloid cells is likely to involve a transcriptional mechanism and 
      keloid overproduction of extracellular matrix components may be due to an 
      inherent modification of the TGF-beta regulatory program.
FAU - Babu, M
AU  - Babu M
AD  - Department of Anatomy and Cell Biology, Tufts University School of Medicine, 
      Boston, MA 02111.
FAU - Diegelmann, R
AU  - Diegelmann R
FAU - Oliver, N
AU  - Oliver N
LA  - eng
GR  - CA43860/CA/NCI NIH HHS/United States
GR  - GM20298/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cell Line, Transformed
MH  - Female
MH  - Fibroblasts/drug effects
MH  - Gene Expression Regulation
MH  - Humans
MH  - Keloid/*pathology
MH  - Male
MH  - Middle Aged
MH  - Transforming Growth Factor beta/genetics/*pharmacology
EDAT- 1992/11/01 00:00
MHDA- 1992/11/01 00:01
CRDT- 1992/11/01 00:00
PHST- 1992/11/01 00:00 [pubmed]
PHST- 1992/11/01 00:01 [medline]
PHST- 1992/11/01 00:00 [entrez]
AID - S0022-202X(92)90695-Z [pii]
AID - 10.1111/1523-1747.ep12668146 [doi]
PST - ppublish
SO  - J Invest Dermatol. 1992 Nov;99(5):650-5. doi: 10.1111/1523-1747.ep12668146.