PMID- 1431683
OWN - NLM
STAT- MEDLINE
DCOM- 19921218
LR  - 20190709
IS  - 0022-0795 (Print)
IS  - 0022-0795 (Linking)
VI  - 135
IP  - 1
DP  - 1992 Oct
TI  - 11 beta-Hydroxysteroid dehydrogenase in the rat ovary: high expression in the 
      oocyte.
PG  - 53-8
AB  - The enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) catalyses the 
      conversion of physiological glucocorticoids to inactive products, thus modifying 
      the access of glucocorticoids to glucocorticoid and mineralocorticoid receptors. 
      Glucocorticoids may affect ovarian function both indirectly and via binding to 
      ovarian receptors. We have demonstrated 11 beta-HSD bioactivity and mRNA 
      expression in rat ovary in vitro. The enzyme was localized to oocytes and luteal 
      bodies immunohistochemically using two antibodies raised against purified rat 
      liver 11 beta-HSD. These data are supported by in-situ hybridization studies, 
      which also localized 11 beta-HSD mRNA expression to oocytes and luteal bodies. 
      The results suggest that 11 beta-HSD may modulate the effects of glucocorticoid 
      on ovarian function.
FAU - Benediktsson, R
AU  - Benediktsson R
AD  - Department of Medicine, University of Edinburgh, Western General Hospital, U.K.
FAU - Yau, J L
AU  - Yau JL
FAU - Low, S
AU  - Low S
FAU - Brett, L P
AU  - Brett LP
FAU - Cooke, B E
AU  - Cooke BE
FAU - Edwards, C R
AU  - Edwards CR
FAU - Seckl, J R
AU  - Seckl JR
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Endocrinol
JT  - The Journal of endocrinology
JID - 0375363
RN  - 0 (RNA, Messenger)
RN  - EC 1.1.- (Hydroxysteroid Dehydrogenases)
RN  - EC 1.1.1.146 (11-beta-Hydroxysteroid Dehydrogenases)
SB  - IM
MH  - 11-beta-Hydroxysteroid Dehydrogenases
MH  - Animals
MH  - Biological Assay
MH  - Blotting, Northern
MH  - Female
MH  - Hydroxysteroid Dehydrogenases/genetics/*metabolism
MH  - Immunohistochemistry
MH  - In Situ Hybridization/methods
MH  - Oocytes/*enzymology
MH  - Ovary/*enzymology
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Wistar
EDAT- 1992/10/01 00:00
MHDA- 1992/10/01 00:01
CRDT- 1992/10/01 00:00
PHST- 1992/10/01 00:00 [pubmed]
PHST- 1992/10/01 00:01 [medline]
PHST- 1992/10/01 00:00 [entrez]
AID - 10.1677/joe.0.1350053 [doi]
PST - ppublish
SO  - J Endocrinol. 1992 Oct;135(1):53-8. doi: 10.1677/joe.0.1350053.