PMID- 1432101 OWN - NLM STAT- MEDLINE DCOM- 19921211 LR - 20191101 IS - 0270-6474 (Print) IS - 1529-2401 (Electronic) IS - 0270-6474 (Linking) VI - 12 IP - 11 DP - 1992 Nov TI - Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain. PG - 4391-402 AB - Cell culture studies with dissociated primary cultures from embryonic rat brain revealed that brain-derived neurotrophic factor (BDNF) promotes the developmental differentiation of both basal forebrain cholinergic and mesencephalic dopaminergic neurons. These studies suggested that, in the adult brain, BDNF may be able to protect cholinergic and dopaminergic neurons from degenerative changes induced by axotomy, similar to the known protective action of NGF in cholinergic neurons. Testing this hypothesis, we found that intraventricular administration of recombinant human BDNF (rhBDNF) to adult rats with transections of the fimbria significantly reduces axotomy-induced degenerative changes of the cholinergic cells in the basal forebrain. No such effect was seen on the dopaminergic neurons of the ventral mesencephalon after transection of their axons ascending in the medial forebrain bundle. Injected in equal amounts, rhBDNF and recombinant human NGF had quantitatively different effects on the cholinergic neurons. BDNF sustained only part of the population of cholinergic neurons affected by the lesion, whereas the entire population was protected by NGF treatment. FAU - Knusel, B AU - Knusel B AD - Division of Neurogerontology, Andrus Gerontology Center, University of Southern California, Los Angeles 90089. FAU - Beck, K D AU - Beck KD FAU - Winslow, J W AU - Winslow JW FAU - Rosenthal, A AU - Rosenthal A FAU - Burton, L E AU - Burton LE FAU - Widmer, H R AU - Widmer HR FAU - Nikolics, K AU - Nikolics K FAU - Hefti, F AU - Hefti F LA - eng GR - AG09793/AG/NIA NIH HHS/United States GR - AG10480/AG/NIA NIH HHS/United States GR - NS22933/NS/NINDS NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - J Neurosci JT - The Journal of neuroscience : the official journal of the Society for Neuroscience JID - 8102140 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Nerve Growth Factors) RN - 0 (Nerve Tissue Proteins) RN - 0 (Recombinant Proteins) RN - N91BDP6H0X (Choline) RN - VTD58H1Z2X (Dopamine) SB - IM MH - Animals MH - Axons/physiology MH - Brain-Derived Neurotrophic Factor MH - Choline/*physiology MH - Denervation MH - Dopamine/physiology MH - Female MH - Nerve Degeneration/*drug effects MH - Nerve Growth Factors/pharmacology MH - Nerve Tissue Proteins/*pharmacology MH - Neurons/*drug effects MH - Prosencephalon/cytology/*drug effects/physiology MH - Rats MH - Rats, Wistar MH - Recombinant Proteins MH - Substantia Nigra/cytology/drug effects PMC - PMC6576000 EDAT- 1992/11/01 00:00 MHDA- 1992/11/01 00:01 PMCR- 1993/05/01 CRDT- 1992/11/01 00:00 PHST- 1992/11/01 00:00 [pubmed] PHST- 1992/11/01 00:01 [medline] PHST- 1992/11/01 00:00 [entrez] PHST- 1993/05/01 00:00 [pmc-release] AID - 10.1523/JNEUROSCI.12-11-04391.1992 [doi] PST - ppublish SO - J Neurosci. 1992 Nov;12(11):4391-402. doi: 10.1523/JNEUROSCI.12-11-04391.1992.