PMID- 1433983
OWN - NLM
STAT- MEDLINE
DCOM- 19921215
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 50
IP  - 8
DP  - 1992 Aug
TI  - [Function, molecular structure and gene expression regulation of nerve growth 
      factor].
PG  - 1910-7
AB  - Nerve growth factor (NGF) is the initially discovered and best characterized 
      target-derived neurotrophic factor. The NGF gene family includes NGF, 
      brain-derived neurotrophic factor (BDNF), neurotrophin (NT)-3, NT-4, and NT-5. 
      The members of this family can interact with the members of trk family of 
      receptor-like protein-tyrosine kinases (trk, trk B and trk C), suggesting that 
      the different trk protein serves as receptor subunits for the different 
      neurotrophins. Meanwhile, some recent reports have shown that exogenous 
      administration of NGF itself or a stimulator of NGF synthesis to damaged neurons 
      have beneficial effects. These findings open the possibility of new therapy for 
      nervous diseases, such as Alzheimer's disease.
FAU - Furukawa, Y
AU  - Furukawa Y
AD  - Department of Molecular Biology, Gifu Pharmaceutical University.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Receptors, Nerve Growth Factor)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Molecular Sequence Data
MH  - Molecular Structure
MH  - Nerve Growth Factors/chemistry/*genetics/physiology
MH  - Nerve Regeneration
MH  - Neurons/physiology
MH  - Promoter Regions, Genetic
MH  - Receptors, Nerve Growth Factor/chemistry/physiology
MH  - Signal Transduction
RF  - 26
EDAT- 1992/08/01 00:00
MHDA- 1992/08/01 00:01
CRDT- 1992/08/01 00:00
PHST- 1992/08/01 00:00 [pubmed]
PHST- 1992/08/01 00:01 [medline]
PHST- 1992/08/01 00:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 1992 Aug;50(8):1910-7.