PMID- 1434125
OWN - NLM
STAT- MEDLINE
DCOM- 19921210
LR  - 20190725
IS  - 0021-5198 (Print)
IS  - 0021-5198 (Linking)
VI  - 59
IP  - 3
DP  - 1992 Jul
TI  - Preventive actions of N-(3-aminopropionyl)-L-histidinato zinc (Z-103) through 
      increases in the activities of oxygen-derived free radical scavenging enzymes in 
      the gastric mucosa on ethanol-induced gastric mucosal damage in rats.
PG  - 267-74
AB  - Z-103 at 1 to 25 mg/kg, p.o. prevented 100% ethanol-induced gastric mucosal 
      lesions in a dose-dependent manner. Z-103 at 3 to 25 mg/kg, p.o. significantly 
      elevated gastric mucosal superoxide dismutase (SOD)-like activity 1 hr after its 
      administration to normal rats. In addition, Z-103 at doses (10 and 25 mg/kg, 
      p.o.) which prevented 100% ethanol-induced gastric lesion further increased 
      gastric mucosal SOD-like and glutathione peroxidase (GSH-px) activities elevated 
      by 60% ethanol. Z-103 (10 and 25 mg/kg) significantly inhibited the increase in 
      thiobarbituric acid-reactive substances in gastric mucosa injured by 60% ethanol. 
      The combination with cycloheximide, a protein synthesis inhibitor, completely 
      abolished the prevention of 60% ethanol-induced gastric mucosal lesions and the 
      elevation of both free radical scavenging enzyme activities in the mucosa by 
      Z-103 (10 mg/kg, p.o.). These results suggest that Z-103 may partly protect rat 
      gastric mucosa against ethanol-induced damage by scavenging oxygen-derived free 
      radicals via increases in the synthesis of SOD-like and GSH-px enzymes in the 
      mucosa.
FAU - Ito, M
AU  - Ito M
AD  - Department of Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
FAU - Shii, D
AU  - Shii D
FAU - Segami, T
AU  - Segami T
FAU - Kojima, R
AU  - Kojima R
FAU - Suzuki, Y
AU  - Suzuki Y
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn J Pharmacol
JT  - Japanese journal of pharmacology
JID - 2983305R
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Dipeptides)
RN  - 0 (Free Radical Scavengers)
RN  - 0 (Organometallic Compounds)
RN  - 0 (Zinc Compounds)
RN  - 0WA1B15A1Z (polaprezinc)
RN  - 3K9958V90M (Ethanol)
RN  - 8HO6PVN24W (Carnosine)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Anti-Ulcer Agents/administration & dosage/*pharmacology
MH  - *Carnosine/*analogs & derivatives
MH  - Dipeptides/administration & dosage/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Ethanol/toxicity
MH  - *Free Radical Scavengers
MH  - Gastric Mucosa/drug effects/*enzymology
MH  - Glutathione Peroxidase/*metabolism
MH  - Male
MH  - Organometallic Compounds/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Superoxide Dismutase/*metabolism
MH  - Zinc/administration & dosage/*pharmacology
MH  - Zinc Compounds
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
AID - 10.1254/jjp.59.267 [doi]
PST - ppublish
SO  - Jpn J Pharmacol. 1992 Jul;59(3):267-74. doi: 10.1254/jjp.59.267.