PMID- 1436210
OWN - NLM
STAT- MEDLINE
DCOM- 19921202
LR  - 20061115
IS  - 0028-2561 (Print)
IS  - 0028-2561 (Linking)
VI  - 24
IP  - 4
DP  - 1992
TI  - [GTP-dependent dopamine reception in central nervous system tissues in the pond 
      snail].
PG  - 451-61
AB  - Guanosine-5'-triphosphate (GTP)-dependent binding of the agonist D1 dopamine (DA) 
      receptor ligand [H3]-SKF 38393 is described. It is shown that binding of [H3]-SKF 
      38393 with two different populations takes place in the presence of guanylyl 
      nucleotides, when they are absent--with one population. It is demonstrated using 
      GDP-alpha-P33 binding analysis that the GDP in equilibrium with GTP exchange rate 
      gets higher as a result of activation of DA receptors in the membrane from the 
      mollusc nervous tissues. Influence of the catalytic subunit of the protein kinase 
      A (cPKA) on the [H3]-SKF 38393 and GDP-alpha-P33 is investigated. Obvious 
      influence of the cPKA on [H3]-SKF 38393 binding is not observed, while basal and 
      DA-induced GDP in equilibrium with GTP exchange in membranes of the mollusc 
      nervous tissues is considerably inhibited.
FAU - Prudnikov, I M
AU  - Prudnikov IM
FAU - Tsyvkin, V N
AU  - Tsyvkin VN
FAU - Kastrikina, T F
AU  - Kastrikina TF
LA  - rus
PT  - English Abstract
PT  - Journal Article
TT  - GTF-zavisimaia retseptsiia dofamina v tkaniiakh tsentral'noi nervnoi sistemy 
      bol'shogo prudovika.
PL  - Ukraine
TA  - Neirofiziologiia
JT  - Neirofiziologiia = Neurophysiology
JID - 0231364
RN  - 0 (Receptors, Dopamine D1)
RN  - 0 (Receptors, Dopamine D2)
RN  - 146-91-8 (Guanosine Diphosphate)
RN  - 86-01-1 (Guanosine Triphosphate)
SB  - IM
MH  - Animals
MH  - Central Nervous System/*physiology
MH  - Guanosine Diphosphate/metabolism
MH  - Guanosine Triphosphate/metabolism/*physiology
MH  - Lymnaea/*physiology
MH  - Membranes/metabolism
MH  - Phosphorylation
MH  - Radioligand Assay
MH  - Receptors, Dopamine D1/*physiology
MH  - Receptors, Dopamine D2/*physiology
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
PST - ppublish
SO  - Neirofiziologiia. 1992;24(4):451-61.