PMID- 1436472
OWN - NLM
STAT- MEDLINE
DCOM- 19921214
LR  - 20220227
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 49
IP  - 2
DP  - 1992 Jul
TI  - The prolonged presence of glia-derived nexin, an endogenous protease inhibitor, 
      in the hippocampus after ischemia-induced delayed neuronal death.
PG  - 397-408
AB  - The presence of glia-derived nexin and glia fibrillary acidic protein (GFAP) was 
      investigated in the hippocampus of Mongolian gerbils (Meriones unguiculatus) 
      after transient forebrain ischemia. Bilateral clamping of the common carotid 
      arteries for 7 min resulted in selective degeneration of CA1 pyramidal cells 
      after a delay of three to four days, the so-called delayed neuronal death. 
      Immunoreactivity for glia-derived nexin was found in astrocytes of all CA1 layers 
      and was detectable until day 90 (the longest survival time studied). Astroglial 
      reactivity was demonstrated in parallel by staining for GFAP. The co-localization 
      of glia-derived nexin and GFAP was confirmed by double immunocytochemistry. 
      Ultrastructural studies showed the exclusive presence of glia-derived nexin in 
      astrocytes, in the vicinity of degenerating and preserved neuronal structures. 
      Perivascular glia was intensely stained, but endothelial cells were devoid of 
      immunoreactivity. Glia-derived nexin is a potent protease inhibitor with in vitro 
      neurite-promoting activity. During adulthood, it is mainly present in the 
      olfactory system, where receptor neurons are constantly being replaced. The 
      ability of astrocytes to renew the expression of glia-derived nexin after 
      selective delayed neuronal death and the prolonged presence of the protease 
      inhibitor in a zone where degeneration occurs in the immediate neighborhood of 
      preserved neuronal elements indicate that glia-derived nexin may play a role in 
      structural rearrangements of the central nervous system.
FAU - Hoffmann, M C
AU  - Hoffmann MC
AD  - Section of Neuroanatomy, Anatomy Institute of the University, Basel, Switzerland.
FAU - Nitsch, C
AU  - Nitsch C
FAU - Scotti, A L
AU  - Scotti AL
FAU - Reinhard, E
AU  - Reinhard E
FAU - Monard, D
AU  - Monard D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Carrier Proteins)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Protease Inhibitors)
RN  - 0 (Protease Nexins)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Amyloid beta-Protein Precursor
MH  - Animals
MH  - Blood-Brain Barrier/physiology
MH  - Brain Ischemia/*metabolism
MH  - Carrier Proteins/*metabolism
MH  - Cell Death/physiology
MH  - Gerbillinae
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Hippocampus/anatomy & histology/*metabolism
MH  - Histocytochemistry
MH  - Male
MH  - Microscopy, Electron
MH  - Neuroglia/*metabolism
MH  - Olfactory Bulb/anatomy & histology/metabolism
MH  - Protease Inhibitors/*metabolism
MH  - Protease Nexins
MH  - Receptors, Cell Surface
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
AID - 0306-4522(92)90105-B [pii]
AID - 10.1016/0306-4522(92)90105-b [doi]
PST - ppublish
SO  - Neuroscience. 1992 Jul;49(2):397-408. doi: 10.1016/0306-4522(92)90105-b.