PMID- 1437993
OWN - NLM
STAT- MEDLINE
DCOM- 19921222
LR  - 20190918
IS  - 1043-6618 (Print)
IS  - 1043-6618 (Linking)
VI  - 26
IP  - 3
DP  - 1992 Oct-Nov
TI  - Presence of tobramycin in kidneys and placentae of Sprague-Dawley rat fetuses and 
      newborns following in utero exposure.
PG  - 277-84
AB  - The maternal-fetal transfer of tobramycin (TBM) was investigated in the rat by 
      means of a microbiological assay, to assess the presence and amount in the 
      kidneys and placentae of fetuses at gestational day (GD) 20, in the kidneys of 
      newborns 6 and 11 days after the end of treatment and in the kidneys of the dams. 
      In the qualitative assay, pregnant rats were injected i.p. with 0, 30, 60 mg/kg 
      b.w. of TBM on GD 10-19. A group of dams treated in parallel with 30 mg/kg b.w. 
      was utilized for a microbiological semiquantitative assay. All litters contained 
      some fetuses showing no detectable TBM accumulation in either kidney or in 
      placentae: at 30 mg/kg/b.w. accumulation appeared more prevalent in placenta than 
      in the kidneys of the corresponding fetuses, as confirmed also by the 
      semiquantitative assay. Some newborns (about 6%) of both groups showed detectable 
      renal TBM residues on the 6th and on the 11th day after the end of treatment. The 
      frequency of newborns showing residues was not obviously related to the dose or 
      the day of sampling, and the concentrations of TBM found were comparable to those 
      observed in fetuses. It is possible that they represent a particularly sensitive 
      subgroup.
FAU - Ferrini, A M
AU  - Ferrini AM
AD  - Laboratorio Alimenti, Istituto Superiore di Sanita, Roma, Italy.
FAU - Aureli, P
AU  - Aureli P
FAU - Ricciardi, C
AU  - Ricciardi C
FAU - Stazi, A V
AU  - Stazi AV
FAU - Macri, C
AU  - Macri C
FAU - Mantovani, A
AU  - Mantovani A
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
RN  - VZ8RRZ51VK (Tobramycin)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Biological Assay
MH  - Female
MH  - Fetus/metabolism
MH  - Kidney/embryology/*metabolism
MH  - Male
MH  - *Maternal-Fetal Exchange
MH  - Placenta/*metabolism
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tobramycin/*pharmacokinetics
EDAT- 1992/10/01 00:00
MHDA- 1992/10/01 00:01
CRDT- 1992/10/01 00:00
PHST- 1992/10/01 00:00 [pubmed]
PHST- 1992/10/01 00:01 [medline]
PHST- 1992/10/01 00:00 [entrez]
AID - 1043-6618(92)91262-F [pii]
AID - 10.1016/1043-6618(92)90216-x [doi]
PST - ppublish
SO  - Pharmacol Res. 1992 Oct-Nov;26(3):277-84. doi: 10.1016/1043-6618(92)90216-x.