PMID- 1438486
OWN - NLM
STAT- MEDLINE
DCOM- 19921222
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 43
IP  - 2
DP  - 1992 Oct
TI  - Opposite actions of oxytocin and vasopressin in the development of 
      cocaine-induced behavioral sensitization in mice.
PG  - 491-4
AB  - Subchronic administration of cocaine induces behavioral sensitization (increasing 
      hypermotility) to a challenge dose of the drug administered 72 h after the 
      cessation of treatment. The effects of repeated administration of the 
      neurohypophyseal hormones oxytocin (OXT) and arginine8-vasopressin (AVP) on the 
      development of behavioral sensitization induced by subchronic treatment with 
      cocaine were investigated in mice. Repeated treatment of OXT and AVP did not 
      modify the locomotor stimulatory effect of the challenge dose of cocaine in 
      cocaine-naive control animals. OXT in a dose of 0.5 microgram (sc) augmented the 
      cocaine-induced behavioral sensitization. In contrast, AVP (0.005-0.5 
      microgram/mouse, sc) dose dependently attenuated the development of sensitization 
      to the hypermotility-inducing effect of cocaine. The results suggest that the 
      behavioral sensitization induced by cocaine can be modulated in opposite 
      directions by neurohypophyseal hormones.
FAU - Sarnyai, Z
AU  - Sarnyai Z
AD  - Institute of Pathophysiology, Albert Szent-Gyorgyi Medical University, Szeged, 
      Hungary.
FAU - Szabo, G
AU  - Szabo G
FAU - Kovacs, G L
AU  - Kovacs GL
FAU - Telegdy, G
AU  - Telegdy G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 50-56-6 (Oxytocin)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Arginine Vasopressin/*pharmacology
MH  - Behavior, Animal/*drug effects
MH  - Cocaine/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Motor Activity/drug effects
MH  - Oxytocin/*pharmacology
EDAT- 1992/10/01 00:00
MHDA- 1992/10/01 00:01
CRDT- 1992/10/01 00:00
PHST- 1992/10/01 00:00 [pubmed]
PHST- 1992/10/01 00:01 [medline]
PHST- 1992/10/01 00:00 [entrez]
AID - 0091-3057(92)90182-F [pii]
AID - 10.1016/0091-3057(92)90182-f [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1992 Oct;43(2):491-4. doi: 10.1016/0091-3057(92)90182-f.