PMID- 1443791
OWN - NLM
STAT- MEDLINE
DCOM- 19921207
LR  - 20151119
IS  - 0003-3898 (Print)
IS  - 0003-3898 (Linking)
VI  - 50
IP  - 1
DP  - 1992
TI  - Erythrocyte metabolic alterations in type I diabetes: relationship to metabolic 
      control.
PG  - 9-13
AB  - Erythrocytes from young type I diabetic patients (n = 11), incubated in their 
      plasma in anaerobic conditions, exhibited higher glucose consumption than cells 
      from controls (n = 11). This increased metabolic activity is believed to reflect 
      erythrocyte alterations dependent on the degree of metabolic control, as glucose 
      consumption was significantly correlated to glycosylated haemoglobin (HbA1) and 
      to glucose levels (P < 0.05 and P < 0.01 respectively). Red cell hexokinase (HK) 
      and pyruvate kinase (PK) activities were similar in both groups whereas 
      phosphofructokinase (PFK) activity was slightly higher in patients' cells (P < 
      0.05). No difference was found between patients and controls for red cell ATP and 
      2.3 diphosphoglycerate (2.3 DPG) levels. However, the concentrations of these 
      glycolytic products seem also closely related to the glucose homeostasis in 
      diabetes. Indeed, within the diabetic group, ATP levels showed a negative 
      relationship with glucose level (P < 0.05) and 2.3 DPG a positive relationship 
      with HbA1 (P < 0.05). In conclusion, higher glycolytic activity is present in 
      young diabetic red cells. This activity as well as ATP and 2.3 DPG levels are 
      related to the degree of short- or long-term diabetic control. These findings 
      stress the importance of a careful metabolic control to avoid haematological 
      disturbances.
FAU - Cauchie, P
AU  - Cauchie P
AD  - Department of Clinical Chemistry, Saint-Pierre University Hospital, Brussels, 
      Belgium.
FAU - Vertongen, F
AU  - Vertongen F
FAU - Bosson, D
AU  - Bosson D
FAU - Dorchy, H
AU  - Dorchy H
LA  - eng
PT  - Journal Article
PL  - France
TA  - Ann Biol Clin (Paris)
JT  - Annales de biologie clinique
JID - 2984690R
RN  - 0 (Biomarkers)
RN  - 0 (Diphosphoglyceric Acids)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
SB  - IM
MH  - Adenosine Triphosphate/blood
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood
MH  - Child
MH  - Diabetes Mellitus, Type 1/*blood
MH  - Diphosphoglyceric Acids/blood
MH  - Erythrocytes/*metabolism
MH  - Female
MH  - Glycolysis
MH  - Humans
MH  - Male
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
PST - ppublish
SO  - Ann Biol Clin (Paris). 1992;50(1):9-13.