PMID- 1446835
OWN - NLM
STAT- MEDLINE
DCOM- 19921230
LR  - 20190707
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 121
IP  - 2
DP  - 1992 Nov 16
TI  - A rat brain-derived neurotrophic factor-encoding gene generates multiple 
      transcripts through alternative use of 5' exons and polyadenylation sites.
PG  - 383-6
AB  - As a first step toward clarification of the transcriptional controls of the gene 
      encoding brain-derived neurotrophic factor (BDNF), we cloned and sequenced a rat 
      genomic DNA fragment carrying this gene. RNA blotting analysis using a probe 
      derived from the 3'-flanking region of BDNF revealed that alternative use of 
      3'-polyadenylation sites generates at least two BDNF transcripts that differ in 
      the size of the 3'-noncoding region. Furthermore, sequence analysis of the 5'-end 
      of the BDNF cDNA revealed the presence of at least six different types of 
      transcripts which were probably derived through alternative use of the multiple 
      5'-exons. Therefore, a single BDNF gene could produce multiple types of 
      transcripts with different noncoding sequences through alternative use of both 
      5'-exons and 3'-transcription termination sites.
FAU - Ohara, O
AU  - Ohara O
AD  - Shionogi Research Laboratories, Shionogi & Co., Ltd. Osaka, Japan.
FAU - Gahara, Y
AU  - Gahara Y
FAU - Teraoka, H
AU  - Teraoka H
FAU - Kitamura, T
AU  - Kitamura T
LA  - eng
SI  - GENBANK/D10938
SI  - GENBANK/M79310
SI  - GENBANK/M81114
SI  - GENBANK/M81115
SI  - GENBANK/M81116
SI  - GENBANK/M81117
SI  - GENBANK/M81118
SI  - GENBANK/M95864
SI  - GENBANK/X65112
SI  - GENBANK/X65113
PT  - Journal Article
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA, Messenger)
RN  - 24937-83-5 (Poly A)
RN  - 9007-49-2 (DNA)
SB  - IM
GS  - BDNF
MH  - Alternative Splicing
MH  - Animals
MH  - Base Sequence
MH  - Brain-Derived Neurotrophic Factor
MH  - Cloning, Molecular
MH  - DNA/genetics
MH  - Exons
MH  - Molecular Sequence Data
MH  - Nerve Growth Factors/*genetics
MH  - Nerve Tissue Proteins/*genetics
MH  - Poly A/metabolism
MH  - RNA Processing, Post-Transcriptional
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Restriction Mapping
EDAT- 1992/11/16 00:00
MHDA- 1992/11/16 00:01
CRDT- 1992/11/16 00:00
PHST- 1992/11/16 00:00 [pubmed]
PHST- 1992/11/16 00:01 [medline]
PHST- 1992/11/16 00:00 [entrez]
AID - 0378-1119(92)90148-I [pii]
AID - 10.1016/0378-1119(92)90148-i [doi]
PST - ppublish
SO  - Gene. 1992 Nov 16;121(2):383-6. doi: 10.1016/0378-1119(92)90148-i.