PMID- 1448488
OWN - NLM
STAT- MEDLINE
DCOM- 19921230
LR  - 20200409
IS  - 0091-3057 (Print)
IS  - 1873-5177 (Electronic)
IS  - 0091-3057 (Linking)
VI  - 43
IP  - 3
DP  - 1992 Nov
TI  - Distinguishing effects of cocaine i.v. and SC on mesoaccumbens dopamineand 
      serotonin release with chloral hydrate anesthesia.
PG  - 929-37
AB  - The effect of i.v. cocaine (0.5 and 1.0 mg/kg) was studied on synaptic 
      concentrations of dopamine (DA) and serotonin [5-hydroxytryptamine (5-HT)] in the 
      mesoaccumbens nerve terminal, the nucleus accumbens (NAcc), in chloral 
      hydrate-anesthetized, male Sprague-Dawley rats (Rattus norvegicus) with in vivo 
      electrochemistry (voltammetry). In further in vivo voltammetric studies, the 
      effects of SC cocaine on synaptic concentrations of DA and 5-HT were studied in 
      the chloral hydrate-anesthetized paradigm in two neuroanatomic substrates, NAcc 
      and mesoaccumbens somatodendrites, the ventral tegmental area (VTA-A10), in a 
      dose-response fashion (10, 20, and 40 mg/kg) in six separate studies. Moreover, 
      in two additional in vivo voltammetric studies, again using the chloral 
      hydrate-anesthetized paradigm, the impulse flow blocker, gamma-butyrolactone 
      (gamma-BL) (750 mg/kg, IP), was studied alone and in combination with SC cocaine 
      (20 mg/kg) to determine whether or not cocaine can act by presynaptic releasing 
      mechanisms for DA and 5-HT. The results show that IV cocaine concurrently and 
      significantly increased DA and 5-HT release in the NAcc (p < 0.001, p < 0.0005, 
      respectively) at both doses tested. Moreover, IV cocaine effects on DA and 5-HT 
      release were significantly and positively correlated (p < 0.01). On the other 
      hand, SC cocaine concurrently and significantly decreased DA and 5-HT release in 
      NAcc (p < 0.0001) and VTA (p < 0.0001) at each separate dose tested. SC cocaine 
      effects on DA and 5-HT release were significantly and positively correlated 
      across dose and neuroanatomic substrate (p < 0.01).(ABSTRACT TRUNCATED AT 250 
      WORDS)
FAU - Broderick, P A
AU  - Broderick PA
AD  - Department of Pharmacology, City University of New York Medical School, NY.
LA  - eng
GR  - 2-S07-RR07132/RR/NCRR NIH HHS/United States
GR  - R01-04755-01/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 333DO1RDJY (Serotonin)
RN  - 418M5916WG (Chloral Hydrate)
RN  - I5Y540LHVR (Cocaine)
RN  - OL659KIY4X (4-Butyrolactone)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - 4-Butyrolactone/pharmacology
MH  - *Anesthesia
MH  - Animals
MH  - *Chloral Hydrate
MH  - Cocaine/administration & dosage/*pharmacology
MH  - Dopamine/*metabolism
MH  - Injections, Intravenous
MH  - Injections, Subcutaneous
MH  - Male
MH  - Microelectrodes
MH  - Nucleus Accumbens/drug effects/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*metabolism
MH  - Synapses/drug effects/metabolism
PMC - PMC7133184
EDAT- 1992/11/01 00:00
MHDA- 1992/11/01 00:01
PMCR- 2002/11/07
CRDT- 1992/11/01 00:00
PHST- 1992/11/01 00:00 [pubmed]
PHST- 1992/11/01 00:01 [medline]
PHST- 1992/11/01 00:00 [entrez]
PHST- 2002/11/07 00:00 [pmc-release]
AID - 0091-3057(92)90427-H [pii]
AID - 10.1016/0091-3057(92)90427-h [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1992 Nov;43(3):929-37. doi: 
      10.1016/0091-3057(92)90427-h.