PMID- 1449501
OWN - NLM
STAT- MEDLINE
DCOM- 19921230
LR  - 20190612
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 189
IP  - 1
DP  - 1992 Nov 30
TI  - Comparison of plasma levels of lipid hydroperoxides and antioxidants in 
      hyperlipidemic Nagase analbuminemic rats, Sprague-Dawley rats, and humans.
PG  - 518-23
AB  - The levels of lipid hydroperoxides and antioxidants in plasma samples from Nagase 
      analbuminemic rats (NAR) and control Sprague-Dawley rats (SDR) were measured in 
      comparison with those from normal human subjects. Cholesteryl ester hydroperoxide 
      (CE-OOH) was detected, but phosphatidylcholine hydroperoxide was not. The levels 
      of CE-OOH and the ratios of CE-OOH/CE were found to increase significantly in the 
      order of human < SDR < NAR, suggesting that oxidative stress increases in the 
      same order. NAR have a significantly lower level of ascorbate and lower ratio of 
      ubiquinol/ubiquinone concentrations than SDR. This also suggests that NAR are 
      subject to more oxidative stress than SDR, since ascorbate and ubiquinol are the 
      most effective plasma antioxidants against oxygen radicals.
FAU - Yamamoto, Y
AU  - Yamamoto Y
AD  - Department of Reaction Chemistry, Faculty of Engineering, University of Tokyo, 
      Japan.
FAU - Wakabayashi, K
AU  - Wakabayashi K
FAU - Niki, E
AU  - Niki E
FAU - Nagao, M
AU  - Nagao M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Antioxidants)
RN  - 0 (Lipid Peroxides)
RN  - 0 (Serum Albumin)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - Humans
MH  - Lipid Peroxides/*blood
MH  - Luminescent Measurements
MH  - Male
MH  - Middle Aged
MH  - Rats
MH  - Rats, Mutant Strains
MH  - Rats, Sprague-Dawley
MH  - Reference Values
MH  - Serum Albumin/*deficiency
EDAT- 1992/11/30 00:00
MHDA- 1992/11/30 00:01
CRDT- 1992/11/30 00:00
PHST- 1992/11/30 00:00 [pubmed]
PHST- 1992/11/30 00:01 [medline]
PHST- 1992/11/30 00:00 [entrez]
AID - 0006-291X(92)91588-H [pii]
AID - 10.1016/0006-291x(92)91588-h [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1992 Nov 30;189(1):518-23. doi: 
      10.1016/0006-291x(92)91588-h.