PMID- 14503789
OWN - NLM
STAT- MEDLINE
DCOM- 20031110
LR  - 20061115
IS  - 1438-4221 (Print)
IS  - 1438-4221 (Linking)
VI  - 293
IP  - 4
DP  - 2003 Aug
TI  - The role of human dendritic cells in meningococcal and listerial meningitis.
PG  - 241-9
AB  - Few bacteria are capable of causing infections of the central nervous system 
      (CNS), one of the most subtly shielded anatomical structures within the human 
      body. Neisseria meningitidis is an important cause of bacterial meningitis and 
      commonly affects otherwise healthy infants and adolescents. In contrast, Listeria 
      monocytogenes is a cause of septicaemia and meningitis in neonates and 
      immunocompromised adults. Dendritic cells (DCs) provide the physical link between 
      the innate and adaptive immune system and play a crucial role in host defence 
      against invading bacterial pathogens. The mechanisms of interaction of L. 
      monocytogenes and N. meningitidis with DCs are entirely distinct. Whereas L. 
      monocytogenes is readily phagocytosed by DCs by a serum-dependent mechanism, N. 
      meningitidis is largely protected against phagocytotic uptake by its 
      polysaccharide capsule. In addition, the pattern of secreted cytokines induced by 
      L. monocytogenes is dominated by interleukin (IL)-12 and IL-18, capable of 
      initiating a Th-1 response, whereas N. meningitidis induces high levels of 
      proinflammatory cytokines. Therefore, we propose distinct functions of DCs in 
      both types of bacterial meningitis.
FAU - Kolb-Maurer, Annette
AU  - Kolb-Maurer A
AD  - Dermatologische Universitatsklinik Wurzburg, Wurzburg, Germany. 
      ankolb@biozentrum.uni-wuerzburg.de
FAU - Kurzai, Oliver
AU  - Kurzai O
FAU - Goebel, Werner
AU  - Goebel W
FAU - Frosch, Matthias
AU  - Frosch M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Germany
TA  - Int J Med Microbiol
JT  - International journal of medical microbiology : IJMM
JID - 100898849
RN  - 0 (Cytokines)
SB  - IM
MH  - Cytokines/biosynthesis
MH  - Dendritic Cells/cytology/immunology/*microbiology
MH  - Humans
MH  - Listeria monocytogenes/immunology/*physiology
MH  - Neisseria meningitidis/immunology/*physiology
MH  - Phagocytosis
RF  - 56
EDAT- 2003/09/25 05:00
MHDA- 2003/11/11 05:00
CRDT- 2003/09/25 05:00
PHST- 2003/09/25 05:00 [pubmed]
PHST- 2003/11/11 05:00 [medline]
PHST- 2003/09/25 05:00 [entrez]
AID - S1438-4221(04)70158-7 [pii]
AID - 10.1078/1438-4221-00266 [doi]
PST - ppublish
SO  - Int J Med Microbiol. 2003 Aug;293(4):241-9. doi: 10.1078/1438-4221-00266.