PMID- 1450475
OWN - NLM
STAT- MEDLINE
DCOM- 19930106
LR  - 20131121
IS  - 1058-2916 (Print)
IS  - 1058-2916 (Linking)
VI  - 38
IP  - 4
DP  - 1992 Oct-Dec
TI  - Current functional status of Symbion total artificial heart recipients after 
      transplantation.
PG  - 804-7
AB  - This multicenter study examines long-term data from the five most experienced 
      North American centers (> 8 total artificial heart [TAH] implants), investigating 
      the functional status of 37 patients who received a Symbion TAH followed by a 
      heart transplant (TX) with post-TX survival > or = 1 year. Primary indications 
      for TAH use included acute cardiogenic shock in 38% (14/37) of patients and 
      deterioration while on the TX waiting list in 35% (13/37). At the time of this 
      study, 86% (32/37) of patients were alive, 94% of whom were functioning at a New 
      York Heart Association (NYHA) classification of I (75% [24/32]) or II (19% 
      [6/32]). NYHA classification before death was I for all five patients who died 40 
      +/- 17 (r = 14-58) months after transplant. Of the 32 surviving patients, 47% 
      (15) were working, 16% (5) were retired, 12% (4) chose not to work, and 9% (3) 
      were in school. The remaining 16% (5) were unable to work due to surgical 
      limitations. After TX, significant infections occurred in 81% (26/32) of patients 
      and rejection in 72% (23/32). At 1 year after TX, creatinine was within normal 
      limits (< or = 1.4 mg/100 ml or 65-125 mol/L) for 41% (13/32) of patients, 1-2 
      times normal for 56% (18/32), and > 2 times normal for 3% (1/32). Although TAH is 
      not required for most patients awaiting TX, the device allows excellent long-term 
      functional status in patients otherwise at risk for death. No long-term problems 
      related to the use of temporary mechanical circulatory support were found.
FAU - Liska, M B
AU  - Liska MB
AD  - Mechanical Devices Division, Minneapolis Heart Institute, Minnesota 55407.
FAU - Johnson, K E
AU  - Johnson KE
FAU - Emery, R W
AU  - Emery RW
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Creatinine/blood
MH  - Follow-Up Studies
MH  - Graft Rejection/epidemiology
MH  - *Heart Transplantation/mortality
MH  - *Heart, Artificial
MH  - Humans
MH  - Incidence
MH  - Middle Aged
MH  - *Preoperative Care
MH  - Surgical Wound Infection/epidemiology/microbiology
MH  - Survival Rate
EDAT- 1992/10/01 00:00
MHDA- 1992/10/01 00:01
CRDT- 1992/10/01 00:00
PHST- 1992/10/01 00:00 [pubmed]
PHST- 1992/10/01 00:01 [medline]
PHST- 1992/10/01 00:00 [entrez]
PST - ppublish
SO  - ASAIO J. 1992 Oct-Dec;38(4):804-7.