PMID- 14505427
OWN - NLM
STAT- MEDLINE
DCOM- 20040923
LR  - 20181130
IS  - 1071-2690 (Print)
IS  - 1071-2690 (Linking)
VI  - 39
IP  - 3-4
DP  - 2003 Mar-Apr
TI  - Transforming growth factor-beta1 enhances the secretion of monocyte 
      chemoattractant protein-1 by the IEC-18 intestinal epithelial cell line.
PG  - 183-6
AB  - Intestinal epithelial cells (IEC) are known to produce monocyte chemoattractant 
      protein-1 (MCP-1). However, MCP-1 production, as with many other cytokines, can 
      be regulated by a network of cytokines present in the environment of the IEC. 
      Both IEC and inflammatory cells have been shown to produce transforming growth 
      factor-beta (TGF-beta), and the regulatory effect of this cytokine on MCP-1 
      secretion by IEC has not been determined. Using the IEC-18 cell line, we have 
      found that TGF-beta1 alone induced the secretion of high levels of MCP-1. 
      Treatment with TGF-beta1 also enhanced the levels of MCP-1 messenger ribonucleic 
      acid. However, costimulation of the cells with TGF-beta1 and interleukin-1beta 
      (IL-1beta) resulted in significant, but less than additive, increases in MCP-1 
      secretion. Finally, the enhancing effect of TGF-beta1 on MCP-1 secretion was not 
      due to IL-6. These results suggest that TGF-beta1 from IEC or inflammatory cells 
      may significantly enhance the secretion of MCP-1 by IEC and play an important 
      role in inflamed mucosal tissues.
FAU - Matagrano, Lisa B
AU  - Matagrano LB
AD  - Department of Biological Sciences, Binghamton University (SUNY), Binghamton, New 
      York 13902-6000, USA.
FAU - Magida, Jason A
AU  - Magida JA
FAU - McGee, Dennis W
AU  - McGee DW
LA  - eng
GR  - DK 54049/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - In Vitro Cell Dev Biol Anim
JT  - In vitro cellular & developmental biology. Animal
JID - 9418515
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-1)
RN  - 0 (Tgfb1 protein, rat)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/*metabolism
MH  - Interleukin-1/pharmacology
MH  - Intestinal Mucosa/cytology/drug effects/*metabolism
MH  - Kinetics
MH  - Rats
MH  - Transforming Growth Factor beta/*pharmacology
MH  - Transforming Growth Factor beta1
EDAT- 2003/09/25 05:00
MHDA- 2004/09/24 05:00
CRDT- 2003/09/25 05:00
PHST- 2003/09/25 05:00 [pubmed]
PHST- 2004/09/24 05:00 [medline]
PHST- 2003/09/25 05:00 [entrez]
AID - 0305032 [pii]
AID - 10.1007/s11626-003-0014-z [doi]
PST - ppublish
SO  - In Vitro Cell Dev Biol Anim. 2003 Mar-Apr;39(3-4):183-6. doi: 
      10.1007/s11626-003-0014-z.