PMID- 14505752
OWN - NLM
STAT- MEDLINE
DCOM- 20031104
LR  - 20190707
IS  - 0015-0282 (Print)
IS  - 0015-0282 (Linking)
VI  - 80 Suppl 2
DP  - 2003 Sep
TI  - Coordinated but depressed expression of human leukocyte antigen-DR, intercellular 
      adhesion molecule-1, and CD14 on peritoneal macrophages in women with pelvic 
      endometriosis.
PG  - 768-75
AB  - OBJECTIVE: To investigate the macrophage response in endometriosis, we determined 
      the expression of human leukocyte antigen (HLA)-DR, intercellular adhesion 
      molecule (ICAM)-1, and CD14 on peritoneal macrophages. DESIGN: Case-control study 
      of immunologic markers. SETTING: University hospital. PATIENT(S): Forty-five 
      Japanese women with endometriosis were compared with 48 control subjects with 
      other laparoscopic diagnoses. INTERVENTION(S): Venipuncture and laparoscopic 
      peritoneal fluid (PF) collection. MAIN OUTCOME MEASURE(S): Expression of HLA-DR, 
      ICAM-1, and CD14 on peripheral blood (PB) monocytes and PF macrophages were 
      quantitated as mean fluorescence intensities by flow cytometry. Expression of 
      each marker on PF macrophages was divided by that on PB monocytes, as an index of 
      macrophage activation (macrophage activation ratio). RESULT(S): In women with 
      endometriosis, PF macrophages showed significant positive correlations between 
      expression of HLA-DR and ICAM-1, HLA-DR and CD14, and ICAM-1 and CD14. However, 
      expression of individual markers on PF macrophages and their activation ratios 
      were significantly lower than in control. CONCLUSION(S): Coordinated but 
      relatively low expression of HLA-DR, ICAM-1, and CD14 on PF macrophages indicates 
      a positive but limited immune response to events in the peritoneal cavity in 
      women with endometriosis, which may induce immune tolerance to implanted or 
      metaplastic endometrial tissue.
FAU - Izumiya, Chiaki
AU  - Izumiya C
AD  - Department of Obstetrics and Gynecology, Kochi Medical School, Kohasu, Oko, 
      Nankoku, Kochi, Japan. izumiyat@med.kochi-ms.ac.jp
FAU - Maeda, Nagamasa
AU  - Maeda N
FAU - Kusume, Tomoaki
AU  - Kusume T
FAU - Masumoto, Takayuki
AU  - Masumoto T
FAU - Yamashita, Chika
AU  - Yamashita C
FAU - Yamamoto, Yorito
AU  - Yamamoto Y
FAU - Oguri, Hiroyoshi
AU  - Oguri H
FAU - Fukaya, Takao
AU  - Fukaya T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Adult
MH  - Ascitic Fluid/immunology
MH  - Case-Control Studies
MH  - Endometriosis/*immunology/metabolism
MH  - Female
MH  - Flow Cytometry
MH  - HLA-DR Antigens/biosynthesis/blood/*immunology
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/biosynthesis/blood/*immunology
MH  - Lipopolysaccharide Receptors/biosynthesis/blood/*immunology
MH  - Macrophage Activation/immunology
MH  - Macrophages, Peritoneal/*immunology/metabolism
MH  - Monocytes/immunology
EDAT- 2003/09/25 05:00
MHDA- 2003/11/05 05:00
CRDT- 2003/09/25 05:00
PHST- 2003/09/25 05:00 [pubmed]
PHST- 2003/11/05 05:00 [medline]
PHST- 2003/09/25 05:00 [entrez]
AID - S0015028203007805 [pii]
AID - 10.1016/s0015-0282(03)00780-5 [doi]
PST - ppublish
SO  - Fertil Steril. 2003 Sep;80 Suppl 2:768-75. doi: 10.1016/s0015-0282(03)00780-5.