PMID- 14505760
OWN - NLM
STAT- MEDLINE
DCOM- 20031104
LR  - 20190707
IS  - 0015-0282 (Print)
IS  - 0015-0282 (Linking)
VI  - 80 Suppl 2
DP  - 2003 Sep
TI  - Streptozotocin-induced diabetic effects on spermatogenesis with proliferative 
      cell nuclear antigen immunostaining of adult rat testis.
PG  - 828-31
AB  - OBJECTIVE: To examine the histopathological effects of diabetes on 
      spermatogenesis and to detect the proliferation of germ cells with proliferative 
      cell nuclear antigen (PCNA). DESIGN: Controlled experimental study. SETTING: The 
      animal laboratory of the Experimental Surgery Center of Ege University, Izmir, 
      Turkey. ANIMAL(S): Ten nondiabetic (control) and 20 diabetic adult male albino 
      rats. INTERVENTION(S): The rats were IP injected with 40 mg/kg streptozotocin for 
      5 days to create a diabetic condition that was confirmed by testing blood glucose 
      levels 5-7 days after the first injection. MAIN OUTCOME MEASURE(S): Mean 
      testicular diameter, mean semniferous tubuli diameter (MSTD), and PCNA index. 
      RESULT(S): Six weeks after the streptozotocin injection, both the mean testicular 
      and the seminiferous tubuli diameters were significantly decreased in diabetic 
      rats compared with the control group. CONCLUSION(S): The effects of diabetes on 
      spermatogenesis can be clearly detected as a decrease in testicular diameter, 
      MSTD, and PCNA index.
FAU - Altay, Baris
AU  - Altay B
AD  - Urology Department, Ege University Medical School, Bornova, Izmir, Turkey. 
      baltay@mail.koc.net
FAU - Cetinkalp, Sevki
AU  - Cetinkalp S
FAU - Doganavsargil, Basak
AU  - Doganavsargil B
FAU - Hekimgil, Mine
AU  - Hekimgil M
FAU - Semerci, Bulent
AU  - Semerci B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (Blood Glucose)
RN  - 0 (Proliferating Cell Nuclear Antigen)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Experimental/*pathology
MH  - Immunohistochemistry
MH  - Male
MH  - Proliferating Cell Nuclear Antigen/*metabolism
MH  - Rats
MH  - Seminiferous Tubules/*pathology
MH  - Spermatogenesis/*physiology
EDAT- 2003/09/25 05:00
MHDA- 2003/11/05 05:00
CRDT- 2003/09/25 05:00
PHST- 2003/09/25 05:00 [pubmed]
PHST- 2003/11/05 05:00 [medline]
PHST- 2003/09/25 05:00 [entrez]
AID - S0015028203009841 [pii]
AID - 10.1016/s0015-0282(03)00984-1 [doi]
PST - ppublish
SO  - Fertil Steril. 2003 Sep;80 Suppl 2:828-31. doi: 10.1016/s0015-0282(03)00984-1.